Gene Pair Information
Gene Pair: RPS27A, RNF2
Related Sentences
| # | PMID | Sentence |
| 1 | 9528852 | BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. |
| 2 | 9528852 | We have identified a novel protein, BAP1, which binds to the RING finger domain of the Breast/Ovarian Cancer Susceptibility Gene product, BRCA1. |
| 3 | 9528852 | BAP1 is a nuclear-localized, ubiquitin carboxy-terminal hydrolase, suggesting that deubiquitinating enzymes may play a role in BRCA1 function. |
| 4 | 9528852 | BAP1 binds to the wild-type BRCA1-RING finger, but not to germline mutants of the BRCA1-RING finger found in breast cancer kindreds. |
| 5 | 9528852 | BAP1 and BRCA1 are temporally and spatially co-expressed during murine breast development and remodeling, and show overlapping patterns of subnuclear distribution. |
| 6 | 9528852 | BAP1 resides on human chromosome 3p21.3; intragenic homozygous rearrangements and deletions of BAP1 have been found in lung carcinoma cell lines. |
| 7 | 9528852 | BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth and is the first nuclear-localized ubiquitin carboxy-terminal hydrolase to be identified. |
| 8 | 9528852 | BAP1 may be a new tumor suppressor gene which functions in the BRCA1 growth control pathway. |