Gene Pair Information
Gene Pair: TCEAL1, RBBP8
Related Sentences
| # | PMID | Sentence |
| 1 | 10196224 | Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. |
| 2 | 10196224 | The ability of BRCA1 to transactivate the p21 promoter can be inactivated by mutation of the conserved BRCA1 C-terminal (BRCT) repeats. |
| 3 | 10196224 | CtIP interacts specifically with the BRCT repeats of BRCA1, both in vitro and in vivo, and tumor-derived mutations in this region abolished these interactions. |
| 4 | 10196224 | The association of BRCA1 with CtIP was also abrogated in cells treated with DNA-damaging agents including UV, gamma-irradiation, and adriamycin, a response correlated with BRCA1 phosphorylation. |
| 5 | 10196224 | The transactivation of the p21 promoter by BRCA1 was diminished by expression of exogenous CtIP and CtBP. |
| 6 | 10196224 | These results suggest that the binding of the BRCT repeats of BRCA1 to CtIP/CtBP is critical in mediating transcriptional regulation of p21 in response to DNA damage. |