Ignet

Gene Pair: XRCC4, LIG4

Related Sentences

#	PMID	Sentence
1	9259561	Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.
2	9705934	DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains.
3	9705934	It has recently been demonstrated that DNA ligase IV interacts with and is catalytically stimulated by the XRCC4 protein [2,3], which is essential for DNA double-strand break repair and the genomic rearrangement process of V(D)J recombination [4].
4	9705934	DNA ligase IV is characterized by a unique carboxy-terminal tail comprising two BRCT (BRCA1 carboxyl terminus) domains.
5	9705934	It has been suggested that DNA ligase IV associates with XRCC4 via its tandem BRCT domains and that this may be a general model for protein-protein interactions between DNA repair proteins [3].
6	9705934	We have performed a detailed deletional analysis of DNA ligase IV to define its XRCC4-binding domain and to characterize regions essential for its catalytic activity.
7	9705934	We find that a region in the carboxy-terminal tail of DNA ligase IV located between rather than within BRCT domains is necessary and sufficient to confer binding to XRCC4.