Ignet

Gene Pair: LRP1, MDM2

Related Sentences

#	PMID	Sentence
1	8912848	Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets.
2	8912848	The genes most frequently amplified and overexpressed were CDK4 (with coamplification of SAS) and MDM2.
3	8912848	Because individual malignant gliomas showed CDK4/SAS amplification but no MDM2 amplification and vice versa, the possibility remained of a common amplification target gene located between CDK4 and MDM2.
4	8912848	All tumors and cell lines were analyzed at eight gene loci and six anonymous loci from 12q13-q15, including seven loci located between CDK4 and MDM2.
5	8912848	These studies revealed two centers of amplification, one at CDK4/SAS and the other at MDM2.
6	8912848	A number of loci located close to either MDM2 or CDK4/SAS, including the genes GADD153, GLI, RAP1B, A2MR, and IFNG, were found to be coamplified in some tumors but not overexpressed consistently.
7	8912848	All amplicons were discontinuous between CDK4/SAS and MDM2.
8	8912848	Our results thus exclude a common amplification target between CDK4/SAS and MDM2 and provide additional evidence that these genes represent two independent targets of selection.