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Gene Information
Gene symbol: ACTC1
Gene name: actin, alpha, cardiac muscle 1
HGNC ID: 143
Synonyms: CMD1R
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | COL1A1 | 1 hits |
| 2 | SOCS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26748724 | Liver fibrosis was induced in Socs1(-/-)Ifng(-/-) mice with dimethylnitrosamine or carbon tetrachloride. |
| 2 | 26748724 | Following fibrogenic treatments, Socs1(-/-)Ifng(-/-) mice showed elevated serum ALT levels and increased liver fibrosis compared to Ifng(-/-) mice. |
| 3 | 26748724 | The livers of SOCS1-deficient mice showed bridging fibrosis, which was associated with increased accumulation of myofibroblasts and abundant collagen deposition. |
| 4 | 26748724 | SOCS1-deficient livers showed increased expression of genes coding for smooth muscle actin, collagen, and enzymes involved in remodeling the extracellular matrix, namely matrix metalloproteinases and tissue inhibitor of metalloproteinases. |
| 5 | 26748724 | Primary HSCs from SOCS1-deficient mice showed increased proliferation in response to growth factors such as HGF, EGF and PDGF, and the fibrotic livers of SOCS1-deficient mice showed increased expression of the Pdgfb gene. |