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Gene Information
Gene symbol: APLP2
Gene name: amyloid beta (A4) precursor-like protein 2
HGNC ID: 598
Synonyms: APPH
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL17D | 1 hits |
| 2 | IL18 | 1 hits |
| 3 | TLR2 | 1 hits |
| 4 | TYK2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28532492 | The pro-inflammatory cytokine genes IL1B and CXCL8 were up-regulated in monocytes and lymphocytes after Matrix-M exposure. |
| 2 | 28532492 | Matrix-M also induced IL12B, IL17A and IFNG in lymphocytes and IFN-α gene expression in MoDCs. |
| 3 | 28532492 | Granulocyte counts, serum amyloid A levels and transcription of IL18 and TLR2 coincided with disease progression in the pigs. |
| 4 | 25156366 | Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis. |
| 5 | 25156366 | The Th17 network, including IL-23 and IL-22, has recently emerged as a critical component in the pathogenesis of psoriasis. |
| 6 | 25156366 | IL-22 and IL-23 signaling is dependent on the JAK family of protein tyrosine kinases, making JAK inhibition an appealing strategy for the treatment of psoriasis. |
| 7 | 25156366 | In this study, we report the activity of SAR-20347, a small molecule inhibitor with specificity for JAK1 and tyrosine kinase 2 (TYK2) over other JAK family members. |
| 8 | 25156366 | In cellular assays, SAR-20347 dose dependently (1 nM-10 μM) inhibited JAK1- and/or TYK2-dependent signaling from the IL-12/IL-23, IL-22, and IFN-α receptors. |
| 9 | 25156366 | In vivo, TYK2 mutant mice or treatment of wild-type mice with SAR-20347 significantly reduced IL-12-induced IFN-γ production and IL-22-dependent serum amyloid A to similar extents, indicating that, in these models, SAR-20347 is probably acting through inhibition of TYK2. |
| 10 | 25156366 | Taken together, these data indicate that targeting both JAK1- and TYK2-mediated cytokine signaling is more effective than TYK2 inhibition alone in reducing psoriasis pathogenesis. |