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Gene Information
Gene symbol: ARHGEF1
Gene name: Rho guanine nucleotide exchange factor (GEF) 1
HGNC ID: 681
Synonyms: P115-RHOGEF, SUB1.5, LBCL2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL16 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20562522 | Cell death of LSCs and LECs is essential for structural luteolysis. |
| 2 | 20562522 | We previously reported that a treatment combining tumor necrosis factor α (TNF) and interferon γ (IFNG) induced cell death in LSCs and that LECs express TNF receptor type I (TNFRI). |
| 3 | 20562522 | To induce cell death in LECs, LECs were treated with TNF or IFNG (0, 0.05, 0.5, 1.0, 2.5 nM) and a combination of TNF (0.5 nM) and IFNG (0.5 nM) for 24 h. |
| 4 | 20562522 | The viability of LECs was reduced by a single treatment with TNF or IFNG dose-dependently (P<0.05). |
| 5 | 20562522 | Cell viability was further decreased by treatment with a combination of TNF and IFNG (P<0.05). |
| 6 | 20562522 | Cells with DNA fragmentation (TUNEL-positive cells) were observed after the treatment with TNF and IFNG. |
| 7 | 20562522 | Semi-quantitative RT-PCR analysis revealed that treatment with IFNG alone or in combination with TNF increased the expression of TNFRI mRNA compared with the control (P<0.05). |
| 8 | 20562522 | In summary, TNF and IFNG increased cell death in cultured bovine LECs. |
| 9 | 20562522 | The upregulation of TNFRI mRNA expression by IFNG suggests that TNF and IFNG synergistically affect the death of LECs resulting in acute luteolysis. |