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Gene Information
Gene symbol: ATG7
Gene name: autophagy related 7
HGNC ID: 16935
Synonyms: GSA7, DKFZp434N0735
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATG3 | 1 hits |
| 2 | IFNB1 | 1 hits |
| 3 | IFNG | 1 hits |
| 4 | MAP1LC3A | 1 hits |
| 5 | STAT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 27172324 | We recently demonstrated that the LC3 conjugation system (ATG7, ATG3, and ATG12-ATG5-ATG16L1) is required to target LC3 and IFNG (interferon, gamma)-inducible GTPases to the parasitophorus vacuole membrane (PVM) of a protist parasite Toxoplasma gondii and consequently for IFNG to control T. gondii infection. |
| 2 | 27172324 | Here we show that not only LC3, but also its homologs (GABARAP, GABARAPL1, and GABARAPL2) localize on the PVM of T. gondii in a conjugation-dependent manner. |
| 3 | 23221969 | IFNB1/interferon (IFN)-β belongs to the type I IFNs and exerts potent antiproliferative, proapoptotic, antiangiogenic and immunemodulatory functions. |
| 4 | 23221969 | We show here that IFNB1 induces autophagy in MCF-7, MDAMB231 and SKBR3 breast cancer cells by measuring the turnover of two autophagic markers, MAP1LC3B/LC3 and SQSTM1/p62. |
| 5 | 23221969 | The induction of autophagy in MCF-7 cells occurred upstream of the negative regulator of autophagy MTORC1, and autophagosome formation was dependent on the known core autophagy molecule ATG7 and the IFNB1 signaling molecule STAT1. |
| 6 | 23221969 | Using siRNA-mediated silencing of several core autophagy molecules and STAT1, we provide evidence that IFNB1 mediates its antiproliferative effects independent of autophagy, while the proapoptotic function of IFNB1 was strongly enhanced in the absence of autophagy. |