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Gene Information
Gene symbol: BEST1
Gene name: bestrophin 1
HGNC ID: 12703
Synonyms: BMD, BEST
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CIITA | 1 hits |
| 2 | CLEC16A | 1 hits |
| 3 | IFNG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23133532 | Polymorphisms in the inflammatory genes CIITA, CLEC16A and IFNG influence BMD, bone loss and fracture in elderly women. |
| 2 | 23133532 | Osteoclast activity and the fine balance between bone formation and resorption is affected by inflammatory factors such as cytokines and T lymphocyte activity, mediated by major histocompatibility complex (MHC) molecules, in turn regulated by the MHC class II transactivator (MHC2TA). |
| 3 | 23133532 | We investigated the effect of functional polymorphisms in the MHC2TA gene (CIITA), and two additional genes; C-type lectin domain 16A (CLEC16A), in linkage disequilibrium with CIITA and Interferon-γ (IFNG), an inducer of CIITA; on bone density, bone resorption markers, bone loss and fracture risk in 75 year-old women followed for up to 10 years (OPRA n = 1003) and in young adult women (PEAK-25 n = 999). |
| 4 | 23133532 | Carriers of CLEC16A and IFNG variant alleles had lower BMD (p<0.05) and ultrasound parameters and a lower risk of incident fracture (CLEC16A, p = 0.011). |
| 5 | 23133532 | In conclusion, variation in inflammatory genes CIITA, CLEC-16A and INFG appear to contribute to bone phenotypes in elderly women and suggest a role for low-grade inflammation and MHC class II expression for osteoporosis pathogenesis. |