Ignet

Gene Information

Gene symbol: C19orf10

Gene name: chromosome 19 open reading frame 10

HGNC ID: 16948

Synonyms: R33729_1, IL25, SF20, IL-25, IL-27

Related Genes

#	Gene Symbol	Number of hits
1	ADAM33	1 hits
2	CD4	1 hits
3	CSF2	1 hits
4	IFNA13	1 hits
5	IFNAR2	1 hits
6	IFNG	1 hits
7	IFNGR1	1 hits
8	IFNGR2	1 hits
9	IL12A	1 hits
10	IL12B	1 hits
11	IL12RB1	1 hits
12	IL12RB2	1 hits
13	IL13	1 hits
14	IL17A	1 hits
15	IL17D	1 hits
16	IL23A	1 hits
17	IL25	1 hits
18	IL27	1 hits
19	IL27RA	1 hits
20	IL33	1 hits
21	IL5	1 hits
22	IRF1	1 hits
23	JAK2	1 hits
24	NFKBIA	1 hits
25	SOCS1	1 hits
26	STAT1	1 hits
27	STAT2	1 hits
28	TBX21	1 hits
29	TGFBR1	1 hits
30	TYK2	1 hits

Related Sentences

#	PMID	Sentence
1	27799314	Whereas R848 significantly reduced IL-5, IL-13, and IL-17, it induced IFN-γ and IL-27.
2	27799314	Whereas R848 significantly reduced IL-5, IL-13, and IL-17, it induced IFN-γ and IL-27.
3	27799314	Moreover, in vitro IL-27 enhanced secretion of IFN-γ whereas it inhibited IL-5 and IL-13, demonstrating its direct effect on attenuating Th2 responses.
4	27799314	Moreover, in vitro IL-27 enhanced secretion of IFN-γ whereas it inhibited IL-5 and IL-13, demonstrating its direct effect on attenuating Th2 responses.
5	26242990	Genetic variants were identified by sequencing the promoter regions and all exons of IFNG, IFNGR1, IFNGR2, IRF1, IL12A, IL12B, IL12RB1, IL12RB2, IL23A, IL23R, IL27, EBI3, IL27RA, IL6ST, SOCS1, STAT1, STAT4, JAK2, TYK2 and TBX21 in 69 DNA samples from Ghana.
6	24925396	Th2 cells produce interleukin (IL)-4 and IL-13, which induce immunoglobulin E production by B cells, and IL-5 that allows recruitment of eosinophils.
7	24925396	Regulatory T (Treg) cells exhibit a CD4+ phenotype and include Foxp3-positive thymic and induced Tregs, as well as Foxp3-negative IL-10-producing cells.
8	24925396	Recently, innate lymphoid type 2 cells (ILC2) have been found to be able to produce high amounts of IL-5 and IL-13 in response to stimulation with IL-25 and IL-33 produced by non-immune cells.
9	24443555	Tregs (Foxp3⁺CD4⁺) are enriched in tumors to foster a tolerant microenvironment that inhibits antitumor immune response.
10	24443555	Tregs (Foxp3⁺CD4⁺) are enriched in tumors to foster a tolerant microenvironment that inhibits antitumor immune response.
11	24443555	Tregs (Foxp3⁺CD4⁺) are enriched in tumors to foster a tolerant microenvironment that inhibits antitumor immune response.
12	24443555	Tregs (Foxp3⁺CD4⁺) are enriched in tumors to foster a tolerant microenvironment that inhibits antitumor immune response.
13	24443555	Tregs (Foxp3⁺CD4⁺) are enriched in tumors to foster a tolerant microenvironment that inhibits antitumor immune response.
14	24443555	IL-27 is reported to regulate the development and function of Tregs in vitro and in vivo; however, the effects of endogenous IL-27 on Tregs in the tumor microenvironment remain elusive.
15	24443555	IL-27 is reported to regulate the development and function of Tregs in vitro and in vivo; however, the effects of endogenous IL-27 on Tregs in the tumor microenvironment remain elusive.
16	24443555	IL-27 is reported to regulate the development and function of Tregs in vitro and in vivo; however, the effects of endogenous IL-27 on Tregs in the tumor microenvironment remain elusive.
17	24443555	IL-27 is reported to regulate the development and function of Tregs in vitro and in vivo; however, the effects of endogenous IL-27 on Tregs in the tumor microenvironment remain elusive.
18	24443555	IL-27 is reported to regulate the development and function of Tregs in vitro and in vivo; however, the effects of endogenous IL-27 on Tregs in the tumor microenvironment remain elusive.
19	24443555	We demonstrated that in the absence of DC-derived IL-27, Tregs were decreased significantly in transplanted B16 melanoma, transplanted EL-4 lymphoma, and MCA-induced fibrosarcoma by using IL-27p28 conditional KO mice.
20	24443555	We demonstrated that in the absence of DC-derived IL-27, Tregs were decreased significantly in transplanted B16 melanoma, transplanted EL-4 lymphoma, and MCA-induced fibrosarcoma by using IL-27p28 conditional KO mice.
21	24443555	We demonstrated that in the absence of DC-derived IL-27, Tregs were decreased significantly in transplanted B16 melanoma, transplanted EL-4 lymphoma, and MCA-induced fibrosarcoma by using IL-27p28 conditional KO mice.
22	24443555	We demonstrated that in the absence of DC-derived IL-27, Tregs were decreased significantly in transplanted B16 melanoma, transplanted EL-4 lymphoma, and MCA-induced fibrosarcoma by using IL-27p28 conditional KO mice.
23	24443555	We demonstrated that in the absence of DC-derived IL-27, Tregs were decreased significantly in transplanted B16 melanoma, transplanted EL-4 lymphoma, and MCA-induced fibrosarcoma by using IL-27p28 conditional KO mice.
24	24443555	Further studies revealed that IL-27 promoted the expression of CCL22, which is established to mediate the recruitment of peripheral Tregs into tumors.
25	24443555	Further studies revealed that IL-27 promoted the expression of CCL22, which is established to mediate the recruitment of peripheral Tregs into tumors.
26	24443555	Further studies revealed that IL-27 promoted the expression of CCL22, which is established to mediate the recruitment of peripheral Tregs into tumors.
27	24443555	Further studies revealed that IL-27 promoted the expression of CCL22, which is established to mediate the recruitment of peripheral Tregs into tumors.
28	24443555	Further studies revealed that IL-27 promoted the expression of CCL22, which is established to mediate the recruitment of peripheral Tregs into tumors.
29	24443555	Tumor-associated DCs were identified as the major source of CCL22 in tumor sites, and IL-27 could induce CCL22 expression in an IL-27R-dependent manner.
30	24443555	Tumor-associated DCs were identified as the major source of CCL22 in tumor sites, and IL-27 could induce CCL22 expression in an IL-27R-dependent manner.
31	24443555	Tumor-associated DCs were identified as the major source of CCL22 in tumor sites, and IL-27 could induce CCL22 expression in an IL-27R-dependent manner.
32	24443555	Tumor-associated DCs were identified as the major source of CCL22 in tumor sites, and IL-27 could induce CCL22 expression in an IL-27R-dependent manner.
33	24443555	Tumor-associated DCs were identified as the major source of CCL22 in tumor sites, and IL-27 could induce CCL22 expression in an IL-27R-dependent manner.
34	24443555	Correlated with a decreased number of Tregs, tumor-infiltrating CD4 T cells were found to produce much more IFN-γ in IL-27p28 KO mice, which highlighted the physiological importance of Tregs in suppressing an antitumor immune response.
35	24443555	Correlated with a decreased number of Tregs, tumor-infiltrating CD4 T cells were found to produce much more IFN-γ in IL-27p28 KO mice, which highlighted the physiological importance of Tregs in suppressing an antitumor immune response.
36	24443555	Correlated with a decreased number of Tregs, tumor-infiltrating CD4 T cells were found to produce much more IFN-γ in IL-27p28 KO mice, which highlighted the physiological importance of Tregs in suppressing an antitumor immune response.
37	24443555	Correlated with a decreased number of Tregs, tumor-infiltrating CD4 T cells were found to produce much more IFN-γ in IL-27p28 KO mice, which highlighted the physiological importance of Tregs in suppressing an antitumor immune response.
38	24443555	Correlated with a decreased number of Tregs, tumor-infiltrating CD4 T cells were found to produce much more IFN-γ in IL-27p28 KO mice, which highlighted the physiological importance of Tregs in suppressing an antitumor immune response.
39	24443555	Overall, our results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
40	24443555	Overall, our results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
41	24443555	Overall, our results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
42	24443555	Overall, our results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
43	24443555	Overall, our results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
44	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
45	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
46	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
47	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
48	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
49	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
50	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
51	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
52	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
53	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
54	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
55	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
56	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
57	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
58	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
59	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
60	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
61	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
62	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
63	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
64	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
65	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
66	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
67	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
68	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
69	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
70	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
71	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
72	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
73	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
74	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
75	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
76	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
77	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
78	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
79	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
80	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
81	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
82	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
83	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
84	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
85	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
86	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
87	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
88	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
89	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
90	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
91	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
92	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
93	21516112	Here we report that interleukin 23 (IL-23) and the transcription factor RORγt drove expression of the cytokine GM-CSF in helper T cells, whereas IL-12, interferon-γ (IFN-γ) and IL-27 acted as negative regulators.
94	21516112	Autoreactive helper T cells specifically lacking GM-CSF failed to initiate neuroinflammation despite expression of IL-17A or IFN-γ, whereas GM-CSF secretion by Ifng(-/-)Il17a(-/-) helper T cells was sufficient to induce experimental autoimmune encephalomyelitis (EAE).
95	19258923	We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.