Ignet

Gene Information

Gene symbol: CCR7

Gene name: chemokine (C-C motif) receptor 7

HGNC ID: 1608

Synonyms: BLR2, CDw197, CD197

Related Genes

#	Gene Symbol	Number of hits
1	B3GAT1	1 hits
2	BCL11B	1 hits
3	BCLAF1	1 hits
4	CASP1	1 hits
5	CCL2	1 hits
6	CCL3	1 hits
7	CCL5	1 hits
8	CCR5	1 hits
9	CCR6	1 hits
10	CD248	1 hits
11	CD27	1 hits
12	CD28	1 hits
13	CD4	1 hits
14	CD83	1 hits
15	CD8A	1 hits
16	CFLAR	1 hits
17	CTLA4	1 hits
18	CX3CR1	1 hits
19	CXCR3	1 hits
20	CXCR6	1 hits
21	DCX	1 hits
22	FAS	1 hits
23	FOS	1 hits
24	GZMH	1 hits
25	ID3	1 hits
26	IFNG	1 hits
27	IL17A	1 hits
28	IL18	1 hits
29	IL2	1 hits
30	IL6	1 hits
31	ITGB2	1 hits
32	KLRC2	1 hits
33	LGALS1	1 hits
34	NCR1	1 hits
35	NCR2	1 hits
36	NFKBIA	1 hits
37	PDC	1 hits
38	RUNX3	1 hits
39	SELL	1 hits
40	TNF	1 hits
41	XIAP	1 hits

Related Sentences

#	PMID	Sentence
1	28407008	RQ-PCR validation of important genes representative for the dataset, including apoptosis (XIAP, CASP1, BCLAF1 and CFLAR), proliferation/development (ID3) and inflammation (CD28, CCR7, CX3CR1 and IFNG) processes largely confirmed the dysregulation in proliferation and apoptosis.
2	27655794	However, CCR7 deficiency did lead to the preferential accumulation of CD8⁺ ATT cells, which was further exacerbated by HFD feeding.
3	27655794	However, CCR7 deficiency did lead to the preferential accumulation of CD8⁺ ATT cells, which was further exacerbated by HFD feeding.
4	27655794	However, CCR7 deficiency did lead to the preferential accumulation of CD8⁺ ATT cells, which was further exacerbated by HFD feeding.
5	27655794	Finally, expression of inflammatory cytokines/chemokines, such as Tnf, Il6, Il1β, Ccl2, and Ccl3, was equally elevated in AT by HFD feeding in CCR7^-/- and WT mice, while Ifng and Il18 were elevated by HFD feeding in CCR7^-/- but not in WT mice.
6	27655794	Finally, expression of inflammatory cytokines/chemokines, such as Tnf, Il6, Il1β, Ccl2, and Ccl3, was equally elevated in AT by HFD feeding in CCR7^-/- and WT mice, while Ifng and Il18 were elevated by HFD feeding in CCR7^-/- but not in WT mice.
7	27655794	Finally, expression of inflammatory cytokines/chemokines, such as Tnf, Il6, Il1β, Ccl2, and Ccl3, was equally elevated in AT by HFD feeding in CCR7^-/- and WT mice, while Ifng and Il18 were elevated by HFD feeding in CCR7^-/- but not in WT mice.
8	27655794	Together, these data suggest that CCR7 plays a role in CD8⁺ATT cell egress, but does not influence ATM accumulation or the metabolic impact of diet-induced obesity.
9	27655794	Together, these data suggest that CCR7 plays a role in CD8⁺ATT cell egress, but does not influence ATM accumulation or the metabolic impact of diet-induced obesity.
10	27655794	Together, these data suggest that CCR7 plays a role in CD8⁺ATT cell egress, but does not influence ATM accumulation or the metabolic impact of diet-induced obesity.
11	27580107	The DNA microarray data were validated by use of a real-time reverse-transcription PCR assay, and expression of the genes FOS, NFKBI, IFNG, CXCR6, CCR5, ITGB2, CCR7, and SELL was assessed.
12	27580107	The DNA microarray data were validated by use of a real-time reverse-transcription PCR assay, and expression of the genes FOS, NFKBI, IFNG, CXCR6, CCR5, ITGB2, CCR7, and SELL was assessed.
13	27580107	Profile analysis also revealed that FOS and NFKBI (genes of transcription factors) were involved in most cell-signaling pathways and that expression of these genes was significantly higher in colostral T cells than in peripheral blood T cells.
14	27580107	Profile analysis also revealed that FOS and NFKBI (genes of transcription factors) were involved in most cell-signaling pathways and that expression of these genes was significantly higher in colostral T cells than in peripheral blood T cells.
15	27580107	Furthermore, CCR7 and SELL (genes of T-cell differentiation markers) in colostral T cells had expression patterns extremely similar to those found in effector or effector memory T cells.
16	27580107	Furthermore, CCR7 and SELL (genes of T-cell differentiation markers) in colostral T cells had expression patterns extremely similar to those found in effector or effector memory T cells.
17	27443592	There was a concomitant decrease in CTLA-4 expression on CD25(hi)Foxp3(+) Treg cells (p=0.0093) and PD-1 levels on CD8(+) T cells (p=0.0002).
18	27443592	Additionally, the frequency of anergic CTLA-4(+)CCR7(+) T cells decreased following vaccination.
19	26286994	We studied age-related changes in DNA methylation and gene expression in CD4+ and CD8+ T cells from younger and older individuals.
20	26286994	Specifically, in CD8+ T cell subset we identified strong inverse correlation between methylation and expression levels in genes associated with T cell mediated immune response (LGALS1, IFNG, CCL5, GZMH, CCR7, CD27 and CD248) and differentiation (SATB1, TCF7, BCL11B and RUNX3).
21	25781472	In the absence of significant changes in other NK cell markers (CD45RO, NKp44, CXCR6, CD57, NKG2C, CCR7, CD62L and CD27), influenza vaccines induced memory NK cells with the distinct feature of intracellular NKp46 expression.
22	25420916	Borrelia burgdorferi, the bacterial agent of Lyme disease, induces the production of type I IFNs by human DCs through TLR7 and TLR9 signaling.
23	25420916	Borrelia burgdorferi, the bacterial agent of Lyme disease, induces the production of type I IFNs by human DCs through TLR7 and TLR9 signaling.
24	25420916	Production of IDO by mDC and pDC populations, present within human PBMCs, was concomitant with increased expression of the DC maturation markers, CD83 and CCR7.
25	25420916	Production of IDO by mDC and pDC populations, present within human PBMCs, was concomitant with increased expression of the DC maturation markers, CD83 and CCR7.
26	25420916	The defects in IDO production and expression of CD83 and CCR7 could be restored by complementation of the mutant with lp36.
27	25420916	The defects in IDO production and expression of CD83 and CCR7 could be restored by complementation of the mutant with lp36.
28	24313359	Peripheral and site-specific CD4(+) CD28(null) T cells from rheumatoid arthritis patients show distinct characteristics.
29	24313359	Proinflammatory CD4(+) CD28(null) T cells are frequently found in the circulation of patients with rheumatoid arthritis (RA), but are less common in the rheumatic joint.
30	24313359	In the present study, we sought to identify functional differences between CD4(+) CD28(null) T cells from blood and synovial fluid in comparison with conventional CD28-expressing CD4(+) T cells.
31	24313359	Forty-four patients with RA, displaying a distinct CD4(+) CD28(null) T cell population in blood, were recruited for this study; the methylation status of the IFNG locus was examined in isolated T cell subsets, and intracellular cytokine production (IFN-γ, TNF, IL-17) and chemokine receptor expression (CXCR3, CCR6 and CCR7) were assessed by flow cytometry on T cells from the two compartments.
32	24313359	Circulating CD4(+) CD28(null) T cells were significantly more hypomethylated in the CNS-1 region of the IFNG locus than conventional CD4(+) CD28(+) T cells and produced higher levels of both IFN-γ and TNF after TCR cross-linking.
33	24313359	CD4(+) CD28(null) T cells from the site of inflammation expressed significantly more CXCR3 and CCR6 compared to their counterparts in blood.
34	24313359	While IL-17A production could hardly be detected in CD4(+) CD28(null) cells from the blood, a significant production was observed in CD4(+) CD28(null) T cells from synovial fluid.
35	24313359	CD4(+) CD28(null) T cells were not only found to differ from conventional CD4(+) CD28(+) T cells in the circulation, but we could also demonstrate that synovial CD4(+) CD28(null) T cells showed additional effector functions (IL-17 coproduction) as compared to the same subset in peripheral blood, suggesting an active role for these cells in the perpetuation of inflammation in the subset of patients having a CD28(null) population.
36	24296812	TNF-α(+) and IFN-γ(+) CD4(+) T cells expressed significantly higher levels of T-box transcription factors T-bet with graded loss of Eomesodermin (Eomes) expression (T-bet(Hi)Eomes(Hi/Lo)) when compared with TNF-α(+) CD4(+) T cells expressing lower levels of both T-bet and Eomes (T-bet(-)Eomes(-)).
37	24296812	TNF-α(+) and IFN-γ(+) CD4(+) T cells expressed significantly higher levels of T-box transcription factors T-bet with graded loss of Eomesodermin (Eomes) expression (T-bet(Hi)Eomes(Hi/Lo)) when compared with TNF-α(+) CD4(+) T cells expressing lower levels of both T-bet and Eomes (T-bet(-)Eomes(-)).
38	24296812	Furthermore, TNF-α(+) and IFN-γ(+) CD4(+) T cells expressed significantly higher levels of perforin and interleukin (IL)-2 and displayed a terminally differentiated phenotype (CCR7(-)CD27(-)CD45RA(-)CD57(+)CD62L(-)).
39	24296812	Furthermore, TNF-α(+) and IFN-γ(+) CD4(+) T cells expressed significantly higher levels of perforin and interleukin (IL)-2 and displayed a terminally differentiated phenotype (CCR7(-)CD27(-)CD45RA(-)CD57(+)CD62L(-)).
40	24296812	In contrast, TNF-α(+) alone CMV-specific CD4(+) T cells were predominantly early-memory phenotype with a proportion of these cells displaying T memory stem-cell phenotype (CD95(+)CD45RA(+)CCR7(+)CD27(+)).
41	24296812	In contrast, TNF-α(+) alone CMV-specific CD4(+) T cells were predominantly early-memory phenotype with a proportion of these cells displaying T memory stem-cell phenotype (CD95(+)CD45RA(+)CCR7(+)CD27(+)).
42	24296812	In vitro stimulation of CMV-specific CD4(+) T cells with viral antigen in the presence of IL-12 was sufficient to dramatically change the transcriptional and functional profile of TNF-α(+) CD4(+) T cells, whereas TNF-α(+) and IFN-γ(+) CD4(+) T cells remained unaltered.
43	24296812	In vitro stimulation of CMV-specific CD4(+) T cells with viral antigen in the presence of IL-12 was sufficient to dramatically change the transcriptional and functional profile of TNF-α(+) CD4(+) T cells, whereas TNF-α(+) and IFN-γ(+) CD4(+) T cells remained unaltered.