Ignet

Gene Information

Gene symbol: CD86

Gene name: CD86 molecule

HGNC ID: 1705

Synonyms: B7.2, B7-2

Related Genes

#	Gene Symbol	Number of hits
1	ADAMDEC1	1 hits
2	CD274	1 hits
3	CD37	1 hits
4	CD80	1 hits
5	CD97	1 hits
6	EMR2	1 hits
7	ICOSLG	1 hits
8	IL10	1 hits
9	IL12A	1 hits
10	ITGAE	1 hits
11	SLAMF8	1 hits
12	SPN	1 hits
13	TNFSF9	1 hits

Related Sentences

#	PMID	Sentence
1	29070650	The increased metastasis was independent of CD4⁺ and CD8⁺ T lymphocytes, but required NK cells and IFNγ.
2	29070650	We found that IL12-YFP reporter mice, whose lungs were injected with B16F10 melanoma, had increased numbers of IL12-expressing CD103⁺ DCs with enhanced CD86 expression.
3	29070650	Analysis of TCGA datasets revealed an association between high expression of BATF3 and IRF8 and improved survival of breast cancer patients; BATF3 expression also significantly correlated with NK-cell receptor genes, IL12, and IFNG Collectively, our findings show that IL12 from CD103⁺ DCs is critical for NK cell-mediated control of tumor metastasis.
4	25411767	The results showed that PE patients exhibited significantly increased expression levels of the B‑cell receptor genes LYN, CD22, SYK, BTK, PTPRC and NFAM1, whereas expression levels of FYN, FCRL4 and LAX1 were significantly decreased compared to those of the control group.
5	25411767	Expression levels of T‑cell‑dependent B‑cell‑activation genes, including EMR2, TNFSF9, CD86, ICOSLG, CD37 and CD97, were significantly upregulated in PE patients, whereas SPN mRNA expression was significantly downregulated compared with those of the control group.
6	25411767	LILRA1 and TLR9 T cell‑independent B‑cell activation mRNAs were significantly upregulated in PE patients compared with those of the control group.
7	25411767	In addition, the expression levels of B‑cell‑activation regulator genes, including CR1, LILRB4 and VAV1, were significantly increased, whereas SLAMF7 expression levels were significantly decreased in PE patients compared with those of the control group.
8	25411767	Furthermore, the expression levels of B‑cell‑activation‑associated cytokine genes demonstrated a significant upregulation of LTA and IL10 and downregulation of L1A, IFNA5, IFNA6, IFNA8, IFNA14, IL2, IL13 and IFNG in PE patients compared to those of the control group.
9	25229656	NK cells in the presence of HPV-VLPs enhanced DC-maturation as shown by an upregulation of CD86 and HLA-DR and an increased production of IL-12p70, but not of the immunosuppressive cytokine IL-10.
10	25229656	This crosstalk between NK cells and DCs needed CD40 interaction and IL-12p70 secretion, whereas NKG2D was not implicated.
11	25219326	Molecular landscape of T cell-mediated rejection in human kidney transplants: prominence of CTLA4 and PD ligands.
12	25219326	CTLA4, CD28, IFNG), macrophages (e.g.
13	25219326	PDL1, CD86, SLAMF8, ADAMDEC1), B cells (e.g.
14	25219326	CD72, BTLA) and IFNG-treated macrophages (e.g.
15	25219326	ANKRD22, AIM2).
16	25219326	In pathway analysis, the top pathways included T cell receptor signaling and CTLA4 costimulation.
17	25219326	The prominence of inhibitors like CTLA4 and PDL1 raises the possibility of active negative controls within the rejecting tissue.
18	23521696	Recently, the programmed death 1/programmed death 1 ligand (PD-1/PD-L1; CD279/CD274) pathway was demonstrated to play a critical role in attenuating T-cell responses and promoting T-cell tolerance during chronic viral infections.
19	23521696	In this study, we examined the expression of PD-1 and PD-L1 on cervical T cells and dendritic cells (DCs), respectively, from 40 women who were HR-HPV-negative (-) or HR-HPV-positive (+) with CIN grades 0, I and II-III.
20	23521696	We also measured interferon-γ, interleukin-12 (IL-12) and IL-10 in cervical exudates.
21	23521696	PD-1 and PD-L1 expression on cervical T cells and DCs, respectively, was associated with HR-HPV positivity and increased in parallel with increasing CIN grade.
22	23521696	The opposite pattern was observed for CD80 and CD86 expression on DCs, which decreased in HR-HPV+ patients in parallel with increasing CIN grade.
23	23521696	Similarly, reduced levels of the T helper type 1 cytokines interferon-γ and IL-12 and increased levels of the T helper type 2 cytokine IL-10 in cervical exudates correlated with HR-HPV positivity and CIN grade.
24	23521696	Our results suggest that up-regulation of the inhibitory PD-1/PD-L1 pathway may negatively regulate cervical cell-mediated immunity to HPV and contribute to the progression of HR-HPV-related CIN.
25	23521696	These results may aid in the development of PD-1/PD-L1 pathway-based strategies for immunotherapy of HR-HPV-related CIN.