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Gene Information
Gene symbol: CRYAB
Gene name: crystallin, alpha B
HGNC ID: 2389
Synonyms: HSPB5
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CXCL10 | 1 hits |
| 2 | CXCL9 | 1 hits |
| 3 | IL10 | 1 hits |
| 4 | IL1B | 1 hits |
| 5 | IL6 | 1 hits |
| 6 | RPS27A | 1 hits |
| 7 | TLR2 | 1 hits |
| 8 | UBD | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24997049 | Exposure of cultured microglia and macrophages to IFN-γ abrogated subsequent IL-10 induction by HSPB5, and strongly promoted HSPB5-triggered release of TNF-α, IL-6, IL-12, IL-1β and reactive oxygen and nitrogen species. |
| 2 | 24997049 | In addition, high levels of CXCL9, CXCL10, CXL11, several guanylate-binding proteins and the ubiquitin-like protein FAT10 were induced by combined activation with IFN-γ and HSPB5. |
| 3 | 24997049 | Together, our data suggest that inflammatory demyelination during MS is selectively associated with IFN-γ-induced re-programming of an otherwise protective response of microglia and macrophages to the endogenous TLR2 agonist HSPB5. |
| 4 | 24997049 | Exposure of cultured microglia and macrophages to IFN-γ abrogated subsequent IL-10 induction by HSPB5, and strongly promoted HSPB5-triggered release of TNF-α, IL-6, IL-12, IL-1β and reactive oxygen and nitrogen species. |
| 5 | 24997049 | In addition, high levels of CXCL9, CXCL10, CXL11, several guanylate-binding proteins and the ubiquitin-like protein FAT10 were induced by combined activation with IFN-γ and HSPB5. |
| 6 | 24997049 | Together, our data suggest that inflammatory demyelination during MS is selectively associated with IFN-γ-induced re-programming of an otherwise protective response of microglia and macrophages to the endogenous TLR2 agonist HSPB5. |
| 7 | 24997049 | Exposure of cultured microglia and macrophages to IFN-γ abrogated subsequent IL-10 induction by HSPB5, and strongly promoted HSPB5-triggered release of TNF-α, IL-6, IL-12, IL-1β and reactive oxygen and nitrogen species. |
| 8 | 24997049 | In addition, high levels of CXCL9, CXCL10, CXL11, several guanylate-binding proteins and the ubiquitin-like protein FAT10 were induced by combined activation with IFN-γ and HSPB5. |
| 9 | 24997049 | Together, our data suggest that inflammatory demyelination during MS is selectively associated with IFN-γ-induced re-programming of an otherwise protective response of microglia and macrophages to the endogenous TLR2 agonist HSPB5. |