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Gene Information
Gene symbol: CX3CL1
Gene name: chemokine (C-X3-C motif) ligand 1
HGNC ID: 10647
Synonyms: NTN, C3Xkine, ABCD-3, CXC3C, CXC3, fractalkine, neurotactin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL4 | 1 hits |
| 2 | CX3CR1 | 1 hits |
| 3 | GZMB | 1 hits |
| 4 | IFIT5 | 1 hits |
| 5 | IFITM5 | 1 hits |
| 6 | IFNA1 | 1 hits |
| 7 | IFNG | 1 hits |
| 8 | IL12B | 1 hits |
| 9 | IL13 | 1 hits |
| 10 | IL17D | 1 hits |
| 11 | IL18 | 1 hits |
| 12 | IL1B | 1 hits |
| 13 | IL22 | 1 hits |
| 14 | MX1 | 1 hits |
| 15 | OASL | 1 hits |
| 16 | RSAD2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 27606804 | Virus-specific CD8+ T cell responses have been investigated extensively through the use of HLA-peptide tetramers but much less is known regarding CMV-specific CD4+ T cells. |
| 2 | 27606804 | CMV-specific CD4+ T cells display a highly differentiated effector memory phenotype and express a range of cytokines, dominated by dual TNF-α and IFN-γ expression, although substantial populations which express IL-4 were seen in some donors. |
| 3 | 27606804 | These include the expression of CX3CR1, which would direct cells towards fractalkine on activated endothelium, and the β2-adrenergic receptor, which could permit rapid response to stress. |
| 4 | 27606804 | CMV-specific CD4+ T cells display an intense cytotoxic profile with high level expression of granzyme B and perforin, a pattern which increases further during aging. |
| 5 | 27071061 | HPAI H5N1 virus induced excessive expression of type I IFNs (IFNA and IFNG), cytokines (IL1B, IL18, IL22, IL13, and IL12B), chemokines (CCL4, CCL19, CCL10, and CX3CL1) and IFN stimulated genes (OASL, MX1, RSAD2, IFITM5, IFIT5, GBP 1, and EIF2AK) in lung tissues. |
| 6 | 20921622 | Enhanced cell cycle and metabolic activity was restricted to the acute phase of the response, but at all stages, HCMV-specific CD8+ T cells expressed the Th1-associated transcription factors T-bet (TBX21) and eomesodermin (EOMES), in parallel with continuous expression of IFNG mRNA and IFN-γ-regulated genes. |
| 7 | 20921622 | The cytolytic proteins granzyme B and perforin as well as the fractalkine-binding chemokine receptor CX3CR1 were found in virus-reactive cells throughout the response. |