Ignet

Gene Information

Gene symbol: CX3CR1

Gene name: chemokine (C-X3-C motif) receptor 1

HGNC ID: 2558

Synonyms: CMKDR1, V28, CCRL1

Related Genes

#	Gene Symbol	Number of hits
1	AKT3	1 hits
2	BCLAF1	1 hits
3	CASP1	1 hits
4	CBLB	1 hits
5	CCR7	1 hits
6	CD28	1 hits
7	CFLAR	1 hits
8	CX3CL1	1 hits
9	DLG1	1 hits
10	FKBP1A	1 hits
11	GZMB	1 hits
12	ID3	1 hits
13	IFNG	1 hits
14	IL2RA	1 hits
15	IL7R	1 hits
16	ITK	1 hits
17	JUN	1 hits
18	MALT1	1 hits
19	NFATC2	1 hits
20	NOG	1 hits
21	PLCG1	1 hits
22	RBM12B	1 hits
23	SPRED1	1 hits
24	XIAP	1 hits

Related Sentences

#	PMID	Sentence
1	28407008	RQ-PCR validation of important genes representative for the dataset, including apoptosis (XIAP, CASP1, BCLAF1 and CFLAR), proliferation/development (ID3) and inflammation (CD28, CCR7, CX3CR1 and IFNG) processes largely confirmed the dysregulation in proliferation and apoptosis.
2	27606804	Virus-specific CD8+ T cell responses have been investigated extensively through the use of HLA-peptide tetramers but much less is known regarding CMV-specific CD4+ T cells.
3	27606804	CMV-specific CD4+ T cells display a highly differentiated effector memory phenotype and express a range of cytokines, dominated by dual TNF-α and IFN-γ expression, although substantial populations which express IL-4 were seen in some donors.
4	27606804	These include the expression of CX3CR1, which would direct cells towards fractalkine on activated endothelium, and the β2-adrenergic receptor, which could permit rapid response to stress.
5	27606804	CMV-specific CD4+ T cells display an intense cytotoxic profile with high level expression of granzyme B and perforin, a pattern which increases further during aging.
6	22984568	Additional validation strategies included significant association of single nucleotide polymorphisms (SNPs) in signature genes with sarcoidosis susceptibility and severity (unbiased signature genes - CX3CR1, FKBP1A, NOG, RBM12B, SENS3, TSHZ2; T cell/JAK-STAT pathway genes such as AKT3, CBLB, DLG1, IFNG, IL2RA, IL7R, ITK, JUN, MALT1, NFATC2, PLCG1, SPRED1).
7	20921622	Enhanced cell cycle and metabolic activity was restricted to the acute phase of the response, but at all stages, HCMV-specific CD8+ T cells expressed the Th1-associated transcription factors T-bet (TBX21) and eomesodermin (EOMES), in parallel with continuous expression of IFNG mRNA and IFN-γ-regulated genes.
8	20921622	The cytolytic proteins granzyme B and perforin as well as the fractalkine-binding chemokine receptor CX3CR1 were found in virus-reactive cells throughout the response.