Ignet

Gene Information

Gene symbol: CXCL1

Gene name: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

HGNC ID: 4602

Synonyms: SCYB1, GROa, MGSA-a, NAP-3

Related Genes

#	Gene Symbol	Number of hits
1	CCL2	1 hits
2	CCL3	1 hits
3	CCL4	1 hits
4	CD40LG	1 hits
5	CD69	1 hits
6	CDC42	1 hits
7	CDH13	1 hits
8	CDH17	1 hits
9	CSF1	1 hits
10	CSF2	1 hits
11	CSF3	1 hits
12	CXCL2	1 hits
13	CXCL3	1 hits
14	CXCL5	1 hits
15	DDX58	1 hits
16	DEFB1	1 hits
17	DSG4	1 hits
18	EGR1	1 hits
19	ESAM	1 hits
20	FASLG	1 hits
21	IFNG	1 hits
22	IL17D	1 hits
23	IL17F	1 hits
24	IL1B	1 hits
25	IL22	1 hits
26	IL6	1 hits
27	IL8	1 hits
28	NFKBID	1 hits
29	NR4A2	1 hits
30	PTGS2	1 hits
31	REG3G	1 hits
32	SLPI	1 hits
33	TNF	1 hits

Related Sentences

#	PMID	Sentence
1	27183578	Analysis of this process showed differential gene expression along with protein levels of proinflammatory markers, including IL-1β, IL-6, IL-12p40, and TNF-α.
2	27183578	These cytokine genes included chemokines (Cxcl1, Cxcl3, Cxcl5, Ccl2, and Ccl3), ILs (Il1b and Ifng), growth factors (Csf2 and Csf3), and TNF family members (Cd40lg).
3	27183578	However, every hemocyanin maintains downregulated key M2 cytokine genes, including Il4 and Il5 Collectively, our data demonstrate that hemocyanins are able to trigger the release of proinflammatory factors with different patterns of cytokine expression, suggesting differential signaling pathways and transcriptional network mechanisms that lead to the activation of M1-polarized macrophages.
4	26690514	Expression of EGR1/2/3, IL8, CXCL1, PTGS2, CD69, IFNG, FASLG, CCL4, CDC42, DDX58, NFKBID and NR4A2 genes were independently validated; EGR1/2/3 and IL8 showed >8-fold higher expression in cases relative to the controls implying their important role in CAD.
5	25965835	These included cadherin 13 (Cdh13), colony stimulating factor 1 (Csf1), chemokine C-X-C motif ligand 1 (Cxcl1), endothelial cell-selective adhesion molecule (Esam), and interferon gamma (Ifng).
6	23668260	The infected mice displayed a significant up-regulation in the expression of chemokines (Cxcl1, Cxcl2 and Ccl2), numerous pro-inflammatory cytokines (Ifng, Il1b, Il6, and Il17f), as well as Il22 and a number of anti-microbial peptides (Defa1, Defa28, Defb1, Slpi and Reg3g) at the site(s) of infection.
7	23668260	However, CD4 T cells of the untreated and C. difficile-infected mice expressed similar levels of CD69 and CD25.
8	23668260	Neither tissue had up-regulated levels of Tbx21, Gata3 or Rorc.
9	23668260	They also displayed significantly higher phosphorylation of AKT and signal transducer and activator of transcription 3 (STAT3), an indication of pro-survival signalling.
10	23668260	These data underscore the local, innate, pro-inflammatory nature of the response to C. difficile and highlight eIF2α phosphorylation and the interleukin-22-pSTAT3-RegIIIγ axis as two of the pathways that could be used to contain and counteract the damage inflicted on the intestinal epithelium.