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Gene Information
Gene symbol: DDX58
Gene name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
HGNC ID: 19102
Synonyms: RIG-I, FLJ13599, DKFZp434J1111
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL4 | 1 hits |
| 2 | CD69 | 1 hits |
| 3 | CDC42 | 1 hits |
| 4 | CXCL1 | 1 hits |
| 5 | DLL1 | 1 hits |
| 6 | DLL4 | 1 hits |
| 7 | EGR1 | 1 hits |
| 8 | FASLG | 1 hits |
| 9 | HIST3H2A | 1 hits |
| 10 | IFNG | 1 hits |
| 11 | IL8 | 1 hits |
| 12 | MYD88 | 1 hits |
| 13 | NFKBID | 1 hits |
| 14 | NR4A2 | 1 hits |
| 15 | PTGS2 | 1 hits |
| 16 | TLR3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28481620 | Using chromatin immunoprecipitation, we observed a reduction of trimethylated histone 3 lysine 9 at the RIG-I promoter. |
| 2 | 26690514 | Expression of EGR1/2/3, IL8, CXCL1, PTGS2, CD69, IFNG, FASLG, CCL4, CDC42, DDX58, NFKBID and NR4A2 genes were independently validated; EGR1/2/3 and IL8 showed >8-fold higher expression in cases relative to the controls implying their important role in CAD. |
| 3 | 25041739 | Dengue virus up-regulates expression of notch ligands Dll1 and Dll4 through interferon-β signalling pathway. |
| 4 | 25041739 | The real-time PCR data showed that Notch ligand Dll1 was significantly induced in DENV-infected monocytes; and receptor Notch4, ligands Dll1 and Dll4, and target Hes1 were dramatically enhanced in DENV-infected macrophages and dendritic cells. |
| 5 | 25041739 | In macrophages, induction of Dll1 and Dll4 mediated by DENV2 was increased by treatment with interferon-β (IFN-β), and was impaired by neutralization of IFN-β. |
| 6 | 25041739 | The DENV-induced Dll1 and Dll4 expression level was decreased by silencing key innate immune molecules, including Toll-like receptor 3 (TLR3), MyD88, RIG-I and IPS-I. |
| 7 | 25041739 | In IFN-receptor-depleted macrophages, the Dll1 and Dll4 induction was significantly alleviated. |
| 8 | 25041739 | Functionally, activation of Notch signalling by Dll1 in CD4(+) T cells enhanced the expression of a T helper type 1 (Th1) cytokine IFN-γ, while Notch activation in macrophages had no direct effect on replication of DENV. |