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Gene Information
Gene symbol: ERN1
Gene name: endoplasmic reticulum to nucleus signaling 1
HGNC ID: 3449
Synonyms: IRE1, IRE1P
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | JUN | 1 hits |
| 2 | MYCN | 1 hits |
| 3 | NMI | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24936061 | A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells. |
| 2 | 24936061 | Based on this approach, we identified N-Myc interactor (NMI) as an IRE1α-interacting/modulator protein in rodent and human pancreatic beta cells. |
| 3 | 24936061 | An increased expression of NMI was detected in islets from nonobese diabetic mice with insulitis and in rodent or human beta cells exposed in vitro to the pro-inflammatory cytokines interleukin-1β and interferon-γ. |
| 4 | 24936061 | Detailed mechanistic studies demonstrated that NMI negatively modulates IRE1α-dependent activation of JNK and apoptosis in rodent and human pancreatic beta cells. |
| 5 | 24936061 | In conclusion, by using a combined omics approach, we identified NMI induction as a novel negative feedback mechanism that decreases IRE1α-dependent activation of JNK and apoptosis in cytokine-exposed beta cells |