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Gene Information
Gene symbol: ESRRB
Gene name: estrogen-related receptor beta
HGNC ID: 3473
Synonyms: ERR2, ERRbeta, NR3B2, ERRb
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | NR2F6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24919548 | Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions. |
| 2 | 24919548 | In particular, a CD4+ T cell intrinsic and non-redundant function of NR2F6 as a potent and selective repressor of the transcription of the pro-inflammatory cytokines interleukin (Il) 2, interferon y (ifng) and consequently of T helper (Th)17 CD4+ T cell-mediated autoimmune disorders has been discovered. |
| 3 | 24919548 | Mechanistically, only sustained high affinity antigen receptor-induced protein kinase C (PKC)-mediated phosphorylation has been shown to inactivate NR2F6, thereby displacing pre-bound NR2F6 from the DNA and, subsequently, allowing for robust NFAT/AP-1- and RORĪ³t-mediated cytokine transcription. |