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Gene Information
Gene symbol: EZH2
Gene name: enhancer of zeste homolog 2 (Drosophila)
HGNC ID: 3527
Synonyms: EZH1, ENX-1, KMT6, KMT6A
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EED | 1 hits |
| 2 | EZH1 | 1 hits |
| 3 | IFNG | 1 hits |
| 4 | IL4 | 1 hits |
| 5 | PCGF2 | 1 hits |
| 6 | RING1 | 1 hits |
| 7 | YY1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24951427 | The epigenetic silencing of cytokine genes is associated with the repressive H3K27 trimethylation mark, mediated by the Ezh2 or Ezh1 methyltransferase components of the polycomb repressive complex 2 (PRC2). |
| 2 | 24951427 | Here we show that silencing of the Ifng, Gata3, and Il10 loci in naïve CD4(+) T cells is dependent on Ezh2. |
| 3 | 24951427 | Naïve CD4(+) T cells lacking Ezh2 were epigenetically primed for overproduction of IFN-γ in Th2 and iTreg and IL-10 in Th2 cells. |
| 4 | 24951427 | In addition, deficiency of Ezh2 accelerated effector Th cell death via death receptor-mediated extrinsic and intrinsic apoptotic pathways, confirmed in vivo for Ezh2-null IFN-γ-producing CD4(+) and CD8(+) T cells responding to Listeria monocytogenes infection. |
| 5 | 18285333 | Nevertheless, the polycomb proteins, YY1, Mel-18, Ring1A, Ezh2, and Eed, bound to the Il4 and Ifng loci in a differential pattern. |
| 6 | 18285333 | Nevertheless, the polycomb proteins, YY1, Mel-18, Ring1A, Ezh2, and Eed, bound to the Il4 and Ifng loci in a differential pattern. |
| 7 | 18285333 | The recruitment of the polycomb proteins Mel-18 and Ezh2 to the cytokine promoters was inhibited in the presence of cyclosporine A, suggesting the involvement of NFAT. |
| 8 | 18285333 | The recruitment of the polycomb proteins Mel-18 and Ezh2 to the cytokine promoters was inhibited in the presence of cyclosporine A, suggesting the involvement of NFAT. |