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Gene Information
Gene symbol: FCGR2A
Gene name: Fc fragment of IgG, low affinity IIa, receptor (CD32)
HGNC ID: 3616
Synonyms: CD32, CD32A, IGFR2, CDw32
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FCGR3A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28972490 | Chronic lymphocytic leukaemia (CLL) is a lymphoproliferative disease characterised by accumulation of monoclonal CD19+CD5+CD23+ lymphocytes in the peripheral blood and bone marrow. |
| 2 | 28972490 | Phagocytic function was assessed through the ability of freshly isolated monocytes to attach and to engulf intact or opsonized Staphylococcus aureus particles in vitro with or without Granulocyte/Macrophage Colony Stimulating Factor (GM-CSF) and Interferon g (IFNg). |
| 3 | 28972490 | Simultaneously, immunophenotyping for FcγRI (CD64), FcγRII (CD32), FcγRIII (CD16) and CD180 has been carried out. |
| 4 | 28972490 | Our results demonstrated that phagocytosis of the intact and opsonised or intact S. aureus by monocytes of CLL patients was significantly decreased in comparison with normal controls, with no recovery upon the treatment with GM-CSF and IFNg. |
| 5 | 28972490 | A significant decrease in the expression of CD64 and CD180 has been detected on monocytes of CLL patients, with the drop in CD64 expression correlating with the disease progression and advanced Rai stages. |
| 6 | 28972490 | No appreciable changes were detected in the expression of CD32 and CD16 throughout the experiments. |
| 7 | 28972490 | The diminished expression of CD64 and CD180 provides possible explanation for the impaired phagocytic function of monocytes in CLL, as FcγRI receptor interaction with opsonising IgG1, and CD180 with the ligands on S. aureus might affect the ability of monocytes to attach and to engulf S. aureus particles and effectively eliminate the pathogen. |