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Gene Information
Gene symbol: FOXP2
Gene name: forkhead box P2
HGNC ID: 13875
Synonyms: CAGH44
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOXP3 | 1 hits |
| 2 | IL10 | 1 hits |
| 3 | TGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 27106476 | Frequently Increased but Functionally Impaired CD4+CD25+ Regulatory T Cells in Patients with Oral Lichen Planus. |
| 2 | 27106476 | Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory mucosal disease, and CD4(+)CD25(+) regulatory T cells (Tregs) are considered involved in the pathogenesis of OLP. |
| 3 | 27106476 | In this study, to investigate whether there are intrinsic factors that might cause functional changes in Tregs in this disease, we evaluated the frequency of Tregs in peripheral blood and oral lesions and the expression levels of function-related transcription factors, forkhead/winged-helix transcription factor box P3 (FOXP3), transforming growth factor β (TGF-β), interleukin 10 (IL-10), and TGF-β receptors (TβRI and TβRII) mRNAs in Tregs of patients with oral lichen planus (OLP). |
| 4 | 27106476 | We also investigated the frequency of pro-inflammatory cytokines (IFN-γ and IL-17A) producing Foxp3(+) regulatory cells. |
| 5 | 27106476 | The percentages of CD4(+)FOXP3(+)IL-17(+) T cells were significantly higher than that of normal controls, whereas the percentages of CD4(+)FOXP3(+)IFN-γ(+) T cells did not differ significantly. |
| 6 | 27106476 | Furthermore, impaired suppressive function of CD4(+)CD25(+) T cells was demonstrated in OLP patients by in vitro proliferation assay. |