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Gene Information
Gene symbol: GATA1
Gene name: GATA binding protein 1 (globin transcription factor 1)
HGNC ID: 4170
Synonyms: ERYF1, NFE1, GATA-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INHBE | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24336657 | Interferon-γ suppresses activin A/NF-E2 induction of erythroid gene expression through the NF-κB/c-Jun pathway. |
| 2 | 24336657 | IFN-γ reduced the mRNA expression of α-globin, ζ-globin, NF-E2p45, and GATA-1 induced by activin A. |
| 3 | 24336657 | The results also showed that IFN-γ induced c-Jun expression when NF-κBp65 and c-Jun bound to two AP-1-binding sites on the c-Jun promoter. |
| 4 | 24336657 | The ability of NF-E2 to enhance activin A-induced ζ-globin promoter activation decreased when c-Jun was present, and IFN-γ treatment further enhanced the decreasing effect of c-Jun. |
| 5 | 24336657 | Chromatin immunoprecipitation revealed that NF-E2p45 bound to the upstream regulatory element (HS-40) of the α-globin gene cluster in response to activin A, whereas c-Jun eliminated this binding. |
| 6 | 24336657 | These results suggest that IFN-γ modulates NF-κB/c-Jun to antagonize activin A-mediated NF-E2 transcriptional activity on globin gene expression. |