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Gene Information
Gene symbol: GIMAP4
Gene name: GTPase, IMAP family member 4
HGNC ID: 21872
Synonyms: HIMAP4, FLJ11110, IMAP4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GIMAP5 | 1 hits |
| 2 | PHF11 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20421878 | PHF11 is a transcriptional co-activator of the Th1 effector cytokine genes, interleukin-2 (IL2) and interferon-γ (IFNG), co-operating with nuclear factor kappa B (NF-κB). |
| 2 | 20421878 | Consistent with its presence in the nucleus, PHF11 was recruited to the IFNG promoter and over-expression of PHF11 increased the binding of NF-κB to the IFNG promoter and IFNG gene transcription. |
| 3 | 20421878 | Over-expression of PHF11 did not increase IL2 gene transcription, suggesting some specificity in promoter recognition. |
| 4 | 20421878 | In contrast, small-interfering RNA knock-down of PHF11 decreased transcription of both IFNG and IL2 and led to decreased CD28 cell-surface expression and reduced NF-κB nuclear import and DNA binding. |
| 5 | 20421878 | Knock-down of PHF11 also decreased cell viability and was accompanied by reduced expression of GIMAP4 and 5 genes required for T-cell differentiation, viability and homeostasis. |