Ignet

Gene Information

Gene symbol: GLI2

Gene name: GLI family zinc finger 2

HGNC ID: 4318

Synonyms: THP2, HPE9, THP1

Related Genes

#	Gene Symbol	Number of hits
1	CCL5	1 hits
2	CD14	1 hits
3	CD44	1 hits
4	COL1A1	1 hits
5	CXCL10	1 hits
6	CXCL9	1 hits
7	DLL3	1 hits
8	FZD9	1 hits
9	GADD45A	1 hits
10	GBP2	1 hits
11	GLI1	1 hits
12	GPNMB	1 hits
13	HMOX1	1 hits
14	IFNG	1 hits
15	IGF1	1 hits
16	IL17B	1 hits
17	KRT5	1 hits
18	LTF	1 hits
19	MPO	1 hits
20	NOTCH2	1 hits
21	NOTCH3	1 hits
22	NQO1	1 hits
23	NUMB	1 hits
24	NUMBL	1 hits
25	S100A8	1 hits
26	S100A9	1 hits
27	SOCS1	1 hits
28	TCF7L2	1 hits

Related Sentences

#	PMID	Sentence
1	25877879	Of these, the potential host responses included up-regulation of genes related to immune response (CD14, S100A8, S100A9, LTF, HP and CHCIL3), up-regulation of Th1-polarizing factor (CCL4, CCL5, CXCL9 and CXCL10), down-regulation of genes related to metabolism (ELANE, IGF1, TCF7L2 and MPO) and no significant response of other genes (GADD45a, GPNMB, HMOX1, IFNG and NQO1) in THP-1 cells infected with MAP.
2	24058673	Hedgehog/GLI signaling activates suppressor of cytokine signaling 1 (SOCS1) in epidermal and neural tumor cells.
3	24058673	Here we show that SOCS1 is a direct target of Hh/GLI signaling in human keratinocytes and medulloblastoma cells.
4	24058673	SOCS1 is a potent inhibitor of interferon gamma (IFN-y)/STAT1 signaling.
5	24058673	The transcription factors GLI1 and GLI2 activate the SOCS1 promoter, which contains five putative GLI binding sites, and GLI2 binding to the promoter was shown by chromatin immunoprecipitation.
6	24058673	Consistent with a role of GLI in SOCS1 regulation, STAT1 phosphorylation is reduced in cells with active Hh/GLI signaling and IFN-у/STAT1 target gene activation is decreased.
7	24058673	Here, we identify SOCS1 as a novel Hh/GLI target gene, indicating a negative role of Hh/GLI pathway in IFN-y/STAT1 signaling.
8	19302234	K562/A02 cells showed a 65-fold higher IC(50) to adriamycin and less intracellular accumulation of adriamycin than K562. cDNA microarray showed marked increases in binding of collagen and cell proliferation-related genes (CD44, DLL3, IL17B, NUMB, and NUMBL) and decreases in signal transduction and transcription factor activity related genes (FZD9, GBP2, GLI1, GLI2, IFNG, KRT5, Notch2, and Notch3).