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Gene Information
Gene symbol: HBB
Gene name: hemoglobin, beta
HGNC ID: 4827
Synonyms: CD113t-C, HBD, beta-globin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CRP | 1 hits |
| 2 | ESR1 | 1 hits |
| 3 | IFNG | 1 hits |
| 4 | IL6 | 1 hits |
| 5 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28601896 | Influence of TNF and IL6 gene polymorphisms on the severity of cytopenias in Argentine patients with myelodysplastic syndromes. |
| 2 | 28601896 | In order to evaluate a possible association between susceptibility and clinic-pathologic features, we genotyped 153 MDS patients for functional cytokine polymorphisms: TNF (-308 G/A), IFNG (+874 A/T and +875 CAn), IL6 (-174 G/C), and TGFB1 (+869 C/T and +915 G/C). |
| 3 | 28601896 | The frequency of TNF and IL6 polymorphisms was different between patients and healthy controls (n = 131), suggesting a relatedness to MDS susceptibility in our population. |
| 4 | 28601896 | Furthermore, the presence of each or both high-producing genotypes [TNF: p = 0.048, odds ratio (OR): 3.979; IL6: p = 0.001, OR: 6.835; both: p = 0.010, OR: 6.068] and thrombocytopenia at platelet counts of <50,000/μL (p = 0.004, OR: 4.857) were independently associated with an increased risk of manifesting a hemoglobin level of <8 g/dL at diagnosis. |
| 5 | 28601896 | Our results demonstrate that TNF and IL6 gene polymorphisms, as underlying host features, are likely to play a key role in influencing the severity of the cytopenias in MDS and they may be instrumental for tailoring cytokine-target therapies. |
| 6 | 25837440 | In particular, MAIT cell numbers were significantly correlated with sputum AFB positivity, extent of disease, hemoglobin levels, lymphocyte counts, CRP and ESR levels. |
| 7 | 25248876 | Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population. |
| 8 | 25248876 | The higher producing IFNG 12 CA-repeat allele showed strong linkage disequilibrium with the + 874T allele, and was associated with a lower hemoglobin level (p = 0.0351). |