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Gene Information
Gene symbol: HES1
Gene name: hairy and enhancer of split 1, (Drosophila)
HGNC ID: 5192
Synonyms: FLJ20408, HES-1, Hes1, bHLHb39
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DLL1 | 1 hits |
| 2 | DLL4 | 1 hits |
| 3 | GPR146 | 1 hits |
| 4 | IFNG | 1 hits |
| 5 | IRF3 | 1 hits |
| 6 | NOTCH4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28464285 | Elimination of GPR146-mediated antiviral function through IRF3/HES1-signalling pathway. |
| 2 | 28464285 | Elimination of GPR146-mediated antiviral function through IRF3/HES1-signalling pathway. |
| 3 | 28464285 | Elimination of GPR146-mediated antiviral function through IRF3/HES1-signalling pathway. |
| 4 | 28464285 | Here, we demonstrated that the expression of G-protein-coupled receptor 146 (GPR146) is highly increased by both IFN-β and IFN-γ in a signal transducer and activator of transcription 1-dependent signalling pathway. |
| 5 | 28464285 | Here, we demonstrated that the expression of G-protein-coupled receptor 146 (GPR146) is highly increased by both IFN-β and IFN-γ in a signal transducer and activator of transcription 1-dependent signalling pathway. |
| 6 | 28464285 | Here, we demonstrated that the expression of G-protein-coupled receptor 146 (GPR146) is highly increased by both IFN-β and IFN-γ in a signal transducer and activator of transcription 1-dependent signalling pathway. |
| 7 | 28464285 | Surprisingly, virus-activated IFN regulatory factor 3 (IRF3) signalling not only induces the expression of IFN but also represses GPR146 expression through HES1 (hairy and enhancer of split-1)-mediated transcriptional activity to establish a dynamic equilibrium between pro-viral and antiviral stages in host cells. |
| 8 | 28464285 | Surprisingly, virus-activated IFN regulatory factor 3 (IRF3) signalling not only induces the expression of IFN but also represses GPR146 expression through HES1 (hairy and enhancer of split-1)-mediated transcriptional activity to establish a dynamic equilibrium between pro-viral and antiviral stages in host cells. |
| 9 | 28464285 | Surprisingly, virus-activated IFN regulatory factor 3 (IRF3) signalling not only induces the expression of IFN but also represses GPR146 expression through HES1 (hairy and enhancer of split-1)-mediated transcriptional activity to establish a dynamic equilibrium between pro-viral and antiviral stages in host cells. |
| 10 | 28464285 | Taken together, these data reveal the antiviral role of GPR146 in fighting viral infection although the GPR146-mediated protection is eliminated by IRF3/HES1-signalling, which suggests a potential therapeutic significance of both GPR146 and HES1 signalling in viral infection. |
| 11 | 28464285 | Taken together, these data reveal the antiviral role of GPR146 in fighting viral infection although the GPR146-mediated protection is eliminated by IRF3/HES1-signalling, which suggests a potential therapeutic significance of both GPR146 and HES1 signalling in viral infection. |
| 12 | 28464285 | Taken together, these data reveal the antiviral role of GPR146 in fighting viral infection although the GPR146-mediated protection is eliminated by IRF3/HES1-signalling, which suggests a potential therapeutic significance of both GPR146 and HES1 signalling in viral infection. |
| 13 | 25041739 | Dengue virus up-regulates expression of notch ligands Dll1 and Dll4 through interferon-β signalling pathway. |
| 14 | 25041739 | The real-time PCR data showed that Notch ligand Dll1 was significantly induced in DENV-infected monocytes; and receptor Notch4, ligands Dll1 and Dll4, and target Hes1 were dramatically enhanced in DENV-infected macrophages and dendritic cells. |
| 15 | 25041739 | In macrophages, induction of Dll1 and Dll4 mediated by DENV2 was increased by treatment with interferon-β (IFN-β), and was impaired by neutralization of IFN-β. |
| 16 | 25041739 | The DENV-induced Dll1 and Dll4 expression level was decreased by silencing key innate immune molecules, including Toll-like receptor 3 (TLR3), MyD88, RIG-I and IPS-I. |
| 17 | 25041739 | In IFN-receptor-depleted macrophages, the Dll1 and Dll4 induction was significantly alleviated. |
| 18 | 25041739 | Functionally, activation of Notch signalling by Dll1 in CD4(+) T cells enhanced the expression of a T helper type 1 (Th1) cytokine IFN-γ, while Notch activation in macrophages had no direct effect on replication of DENV. |