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Gene Information
Gene symbol: HLA-B
Gene name: major histocompatibility complex, class I, B
HGNC ID: 4932
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCR5 | 1 hits |
| 2 | CD4 | 1 hits |
| 3 | CTLA4 | 1 hits |
| 4 | HAVCR2 | 1 hits |
| 5 | HLA-DOB | 1 hits |
| 6 | HLA-DRB1 | 1 hits |
| 7 | IFNAR1 | 1 hits |
| 8 | IFNB1 | 1 hits |
| 9 | IFNG | 1 hits |
| 10 | IL2RA | 1 hits |
| 11 | IL7R | 1 hits |
| 12 | MUC1 | 1 hits |
| 13 | PDCD1 | 1 hits |
| 14 | TGFA | 1 hits |
| 15 | TGFB1 | 1 hits |
| 16 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28257599 | Immunosuppressive drugs affect interferon (IFN)-γ and programmed cell death 1 (PD-1) kinetics in patients with newly diagnosed autoimmune hepatitis. |
| 2 | 28257599 | Herein we investigate the in-vitro effects of prednisolone, 6-mercaptopurine, cyclosporin, tacrolimus, mycophenolic acid (MPA) and rapamycin, immunosuppressive drugs (ISDs) used in AIH treatment, on the expression of proinflammatory cytokines, co-inhibitory molecules and ability to proliferate of CD4+ CD25- cells, isolated from the peripheral blood of treatment-naive patients with AIH. |
| 3 | 28257599 | We note that in healthy subjects (HS) following polyclonal stimulation and in the absence of ISDs, the expression of interferon (IFN)-γ, interleukin (IL)-17 and tumour necrosis factor (TNF)-α by CD4 effectors peaks at 48 h and decreases at 96 h to reach baseline levels. |
| 4 | 28257599 | Levels of programmed cell death-1 (PD-1), T cell immunoglobulin and mucin domain-containing molecule-3 (TIM-3) and cytotoxic T lymphocyte antigen-4 (CTLA-4) increase over 96-h culture both in HS and AIH, although with faster kinetics in the latter. |
| 5 | 28257599 | Exposure to ISDs contains IFN-γ and PD-1 expression in AIH, where control over CD4+ CD25- cell proliferation is also noted upon exposure to MPA. |
| 6 | 28257599 | Treatment with tacrolimus and cyclosporin render CD4+ CD25- cells more susceptible to Treg control. |
| 7 | 23798565 | Suppression is associated with development of a regulatory population of donor CD4(+) CD25(+)T-cells that express high levels of cytotoxic T-lymphocyte antigen 4 (CTLA-4). |
| 8 | 23798565 | CTLA-4 is a negative regulator of T-cell responses and is associated with the induction of tolerogenic dendritic cells (DCs) that produce indoleamine 2,3-dioxygenase (IDO). |
| 9 | 23798565 | Here, we show that despite increased expression of Ifng, Irf3, Irf7, Ido1, and Ido2 in the lymph nodes of TCDD-treated host mice, inhibition of IDO enzyme activity by 1-methyl-tryptophan was unable to relieve TCDD-mediated suppression of the GVH response. |
| 10 | 22295566 | Complex association analysis of copaxone (glatiramer acetate) immunotherapy efficacy with allelic polymorphism in the number of immune response genes, which encode interferone beta (IFNB1), transforming growth factor beta1 (TGFB1), interferone gamma (IFNG), tumor necrosis factor (TNF), interferon alpha/beta receptor 1 (IFNAR1), CC chemokine receptor 5 (CCR5), interleukin 7 receptor alpha subunit (IL7RA), cytotoxic T-lymphocyte antigen 4 (CTLA4) and HLA class II histocompatibility antigen beta chain (DRB1) was performed with APSampler algorithm for 285 multiple sclerosis patients of Russian ethnicity. |
| 11 | 22295566 | The results show evidence for the contribution of polymorphic variants in CCRS, DRB1, IFNG, TGFB1, IFNAR1, IL7RA and, probably, TNF and CTLA4 genes to copaxone treatment response. |
| 12 | 22295566 | Single alleles of CCR5 and DRB1 genes are reliably associated with treatment efficacy. |