Ignet

Gene Information

Gene symbol: HMGB1

Gene name: high mobility group box 1

HGNC ID: 4983

Synonyms: HMG3, SBP-1, DKFZp686A04236

Related Genes

#	Gene Symbol	Number of hits
1	AIM2	1 hits
2	ANGPT2	1 hits
3	CASP1	1 hits
4	CD14	1 hits
5	FCN2	1 hits
6	HSPA1B	1 hits
7	HSPA1L	1 hits
8	IFNG	1 hits
9	IL10	1 hits
10	IL17F	1 hits
11	IL18	1 hits
12	IL1A	1 hits
13	IL1B	1 hits
14	IL1RN	1 hits
15	IL2	1 hits
16	IL4	1 hits
17	IL6	1 hits
18	IL8	1 hits
19	LTA	1 hits
20	MASP2	1 hits
21	MBL2	1 hits
22	MMP9	1 hits
23	MYD88	1 hits
24	MYLK	1 hits
25	NFKB1	1 hits
26	NLRP3	1 hits
27	NOD1	1 hits
28	NOD2	1 hits
29	SERPINE1	1 hits
30	TLR1	1 hits
31	TLR2	1 hits
32	TLR4	1 hits
33	TLR9	1 hits
34	TNF	1 hits

Related Sentences

#	PMID	Sentence
1	27806943	Incubation of the chorioamniotic membranes with HMGB1 1) induced the release of mature IL-1beta and IL-6; 2) upregulated the mRNA expression of the pro-inflammatory mediators NFKB1, IL6, TNF, IL1A, IFNG, and HMGB1 receptors RAGE and TLR2; 3) upregulated the mRNA expression of the inflammasome components NLRP3 and AIM2 as well as NOD proteins (NOD1 and NOD2); 4) increased the protein concentrations of NLRP3 and NOD2; 5) increased the concentration of caspase-1 and the quantity of its active form (p20); and 6) upregulated the mRNA expression and active form of MMP-9.
2	26582197	CD4(+) T-cells in systemic lupus erythematosus (SLE) patients show altered T-cell receptor signaling, which utilizes Fc-receptor γ-chain FcRγ-Syk.
3	26582197	In this study, we show that the ICs present in SLE patients by ligating to FcγRIIIa on CD4(+) T-cells phosphorylate Syk and provide a co-stimulatory signal to CD4(+) T-cells in the absence of CD28 signal.
4	26582197	This led to the development of pathogenic IL-17A(+) and IFN-γ(high) CD4(+) T-cells in vitro.
5	26582197	Cytokines IL-1β, IL-6, TGF-β1, and IL-23 were the only requirement for the development of both populations.
6	26582197	SLE patients CD4(+) T-cells that expressed CD25, CD69, and CD98 bound to ICs showed pSyk and produced IFN-γ and IL-17A.
7	26582197	FcγRIIIa-pSyk up-regulated several toll-like receptor genes as well as the HMGB1 and MyD88 gene transcripts.
8	26473437	The following genes have been studied in populations of trauma patients: CD14, HMGB1, IFNG, IL1A, IL1B, IL1RN, IL4, IL6, IL8, IL10, IL17F, IL18, MBL2, MASP2, FCN2, TLR1, TLR2, TLR4, TLR9, TNF, LTA, GR, MYLK, NLRP3, PRDX6, RAGE, HSPA1B, HSPA1L, HSP90, SERPINE1, IRAK1, IRAK3, VEGFA, LY96, ANGPT2, LBP, MicroRNA, and mtDNA.
9	22660171	We have demonstrated that HMGB1 is detected at high levels in the serum of IL2-treated mice with translocation to the cytoplasm from the nucleus in the liver, consistent with HMGB1's release in response to stress, and ability to sustain autophagy.
10	22660171	We have demonstrated that HMGB1 is detected at high levels in the serum of IL2-treated mice with translocation to the cytoplasm from the nucleus in the liver, consistent with HMGB1's release in response to stress, and ability to sustain autophagy.
11	22660171	Limiting autophagy in mice with coadministration of chloroquine (CQ) diminishes serum levels of HMGB1, cytokines (IFNG and IL6 but not IL18), and autophagic flux, attenuating weight gain, enhancing DC, T-cell and NK cell numbers, and promoting long-term tumor control in a murine hepatic metastases model.
12	22660171	Limiting autophagy in mice with coadministration of chloroquine (CQ) diminishes serum levels of HMGB1, cytokines (IFNG and IL6 but not IL18), and autophagic flux, attenuating weight gain, enhancing DC, T-cell and NK cell numbers, and promoting long-term tumor control in a murine hepatic metastases model.