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Gene Information
Gene symbol: HTRA1
Gene name: HtrA serine peptidase 1
HGNC ID: 9476
Synonyms: HtrA, IGFBP5-protease
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IRF6 | 1 hits |
| 2 | MAPK1 | 1 hits |
| 3 | STAT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24907345 | In this study, we demonstrated that IFN-γ significantly inhibited the basal and LPS-induced HTRA1 expression in fibroblasts and macrophages, which are two major cells for HTRA1 production in RA. |
| 2 | 24907345 | Importantly, the inhibitory effect of IFN-γ on HTRA1 expression was evidenced in collagen-induced arthritis (CIA) mouse models and in human RA synovial cells. |
| 3 | 24907345 | Mechanistically, IFN-γ negatively controls HTRA1 expression through activation of p38 MAPK/STAT1 pathway. |
| 4 | 24907345 | In this study, we demonstrated that IFN-γ significantly inhibited the basal and LPS-induced HTRA1 expression in fibroblasts and macrophages, which are two major cells for HTRA1 production in RA. |
| 5 | 24907345 | Importantly, the inhibitory effect of IFN-γ on HTRA1 expression was evidenced in collagen-induced arthritis (CIA) mouse models and in human RA synovial cells. |
| 6 | 24907345 | Mechanistically, IFN-γ negatively controls HTRA1 expression through activation of p38 MAPK/STAT1 pathway. |