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Gene Information
Gene symbol: IGF1R
Gene name: insulin-like growth factor 1 receptor
HGNC ID: 5465
Synonyms: JTK13, CD221, IGFIR, MGC18216, IGFR
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IGF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28611056 | Acromegaly is characterized by growth hormone (GH) and insulin-like growth factor 1 (IGF1) excess and is accompanied by an increased cardiovascular diseases (CVD) risk. |
| 2 | 28611056 | The underlying signalling pathways were investigated by the inhibition of downstream targets of the IGF1 receptor. |
| 3 | 28611056 | GH did not affect TLR-induced cytokine production, but co-stimulation with IGF1 dose dependently increased the TLR ligand-induced production of IL6 (P < 0.01), TNF alpha (P = 0.02) and IFNg (P < 0.01), as well as the production of the anti-inflammatory cytokine IL10 (P = 0.01). |
| 4 | 28611056 | IGF1 had no effect on IL1B, IL17 and IL22 production. |
| 5 | 28611056 | Inhibition of the MAPK pathway, but not mTOR, completely abrogated the synergistic effect of IGF1 on the LPS-induced IL6 and TNF alpha production. |