Ignet

Gene Information

Gene symbol: IL27

Gene name: interleukin 27

HGNC ID: 19157

Synonyms: IL-27, p28, IL27p28, IL-27A, IL27A, MGC71873

Related Genes

#	Gene Symbol	Number of hits
1	ADAM33	1 hits
2	C19orf10	1 hits
3	CD4	1 hits
4	IFNA13	1 hits
5	IFNAR2	1 hits
6	IL12A	1 hits
7	IL17D	1 hits
8	NFKBIA	1 hits
9	STAT2	1 hits
10	TGFBR1	1 hits

Related Sentences

#	PMID	Sentence
1	24443555	Tregs (Foxp3⁺CD4⁺) are enriched in tumors to foster a tolerant microenvironment that inhibits antitumor immune response.
2	24443555	Tregs (Foxp3⁺CD4⁺) are enriched in tumors to foster a tolerant microenvironment that inhibits antitumor immune response.
3	24443555	IL-27 is reported to regulate the development and function of Tregs in vitro and in vivo; however, the effects of endogenous IL-27 on Tregs in the tumor microenvironment remain elusive.
4	24443555	IL-27 is reported to regulate the development and function of Tregs in vitro and in vivo; however, the effects of endogenous IL-27 on Tregs in the tumor microenvironment remain elusive.
5	24443555	We demonstrated that in the absence of DC-derived IL-27, Tregs were decreased significantly in transplanted B16 melanoma, transplanted EL-4 lymphoma, and MCA-induced fibrosarcoma by using IL-27p28 conditional KO mice.
6	24443555	We demonstrated that in the absence of DC-derived IL-27, Tregs were decreased significantly in transplanted B16 melanoma, transplanted EL-4 lymphoma, and MCA-induced fibrosarcoma by using IL-27p28 conditional KO mice.
7	24443555	Further studies revealed that IL-27 promoted the expression of CCL22, which is established to mediate the recruitment of peripheral Tregs into tumors.
8	24443555	Further studies revealed that IL-27 promoted the expression of CCL22, which is established to mediate the recruitment of peripheral Tregs into tumors.
9	24443555	Tumor-associated DCs were identified as the major source of CCL22 in tumor sites, and IL-27 could induce CCL22 expression in an IL-27R-dependent manner.
10	24443555	Tumor-associated DCs were identified as the major source of CCL22 in tumor sites, and IL-27 could induce CCL22 expression in an IL-27R-dependent manner.
11	24443555	Correlated with a decreased number of Tregs, tumor-infiltrating CD4 T cells were found to produce much more IFN-γ in IL-27p28 KO mice, which highlighted the physiological importance of Tregs in suppressing an antitumor immune response.
12	24443555	Correlated with a decreased number of Tregs, tumor-infiltrating CD4 T cells were found to produce much more IFN-γ in IL-27p28 KO mice, which highlighted the physiological importance of Tregs in suppressing an antitumor immune response.
13	24443555	Overall, our results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
14	24443555	Overall, our results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
15	23464355	Interleukin-27 (IL-27) is a heterodimeric cytokine of the IL-12 family that is produced primarily by antigen-presenting cells and is immunosuppressive toward a variety of immune cell types.
16	23464355	We show that IL-27 gene expression is elevated in cord blood-derived macrophages relative to macrophages originating from healthy adults.
17	23464355	We also evaluated the duration over which elevated IL-27 gene expression may impact immune responses in mice.
18	23464355	Age-dependent analysis of IL-27 gene expression indicated that levels of IL-27 remained significantly elevated throughout infancy and then declined in adult mice.
19	23464355	Neutralization of IL-27 in neonatal macrophages improved the ability of these cells to limit bacterial replication.
20	23464355	Moreover, neutralization of IL-27 during incubation with the Mycobacterium bovis bacillus Calmette-Guérin vaccine augmented the level of interferon-γ elicited from allogeneic CD4+ T lymphocytes.
21	23464355	This suggests that blocking IL-27 during vaccination and infection may improve immune responses in newborn and infant populations.
22	19258923	We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.