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PMID |
Sentence |
1 |
12107440
|
Mutant MECP2 was expressed at normal transcript and protein levels, and exhibited no significant effect on acetylated histones or methyl-binding protein 3 (MBD3) levels.
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2 |
12107440
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The allelic expression of three different imprinted genes (SNRPN, IPW and IGF2) was examined by RT-PCR and RFLP analysis, and demonstrated normal monoallelic expression of all RTT clones.
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3 |
12107440
|
We also examined the expression of five imprinted genes (SNRPN, IPW, NECDIN, H19 and IGF2) in RTT brain samples and observed exclusive monoallelic expression.
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4 |
12107440
|
In conclusion, our results do not support an essential role for either MeCP2 or HDAC in the silencing of several imprinted genes.
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5 |
12107440
|
Mutant MECP2 was expressed at normal transcript and protein levels, and exhibited no significant effect on acetylated histones or methyl-binding protein 3 (MBD3) levels.
|
6 |
12107440
|
The allelic expression of three different imprinted genes (SNRPN, IPW and IGF2) was examined by RT-PCR and RFLP analysis, and demonstrated normal monoallelic expression of all RTT clones.
|
7 |
12107440
|
We also examined the expression of five imprinted genes (SNRPN, IPW, NECDIN, H19 and IGF2) in RTT brain samples and observed exclusive monoallelic expression.
|
8 |
12107440
|
In conclusion, our results do not support an essential role for either MeCP2 or HDAC in the silencing of several imprinted genes.
|