Ignet

Gene Information

Gene symbol: ISG15

Gene name: ISG15 ubiquitin-like modifier

HGNC ID: 4053

Synonyms: IFI15, UCRP

Related Genes

#	Gene Symbol	Number of hits
1	B2M	1 hits
2	CORO1A	1 hits
3	CXCL10	1 hits
4	CXCL11	1 hits
5	CXCL9	1 hits
6	DUSP14	1 hits
7	IFI27	1 hits
8	IFI6	1 hits
9	IFNA1	1 hits
10	IFNG	1 hits
11	IL18R1	1 hits
12	IRF1	1 hits
13	IRF9	1 hits
14	MASP2	1 hits
15	MBL2	1 hits
16	MX1	1 hits
17	NOS2A	1 hits
18	OAS2	1 hits
19	SLA	1 hits
20	SLC11A1	1 hits
21	STAT1	1 hits
22	STAT2	1 hits
23	TLR1	1 hits
24	VDR	1 hits

Related Sentences

#	PMID	Sentence
1	26559095	Many genes involved in tuberculosis susceptibility (e.g., NRAMP1 (SLC11A1), IFNG, NOS2A, VDR, ISG15, TACO, TLR1, TLR, IL18R1, chemokines, PADI, DUSP14, MBL, and MASP-2) have been subjected to epigenetic modification.
2	19848299	By Day 12 of pregnancy, estrogens increase the expression of multiple genes in the uterine luminal epithelium including SPP1, STC1, IRF2 and STAT1 that likely have roles for implantation.
3	19848299	By Day 15 of pregnancy, IFNs upregulate a large array of IFN responsive genes in the underlying stroma and glandular epithelium including ISG15, IRF1, STAT1, SLAs and B2M that likely have roles in uterine remodeling to support placentation.
4	15661146	The most noteworthy changes in gene expression mainly affected the transcriptional network regulated by interferons (IFNs), including both IFN-alpha/beta-inducible genes (STAT1, STAT2, ISGF3G/IRF9, IFI27, G1P3, G1P2, OAS2, MX1) and IFN-gamma-inducible genes (CXCL9, CXCL10, CXCL11).
5	15661146	Interesting, upregulation of IFN-alpha/beta-inducible genes (but not IFN-gamma-inducible genes) was independent of histological scores (grade and stage of fibrosis) and HCV characteristics (hepatic HCV mRNA levels and the HCV genotype), and was specific to HCV (as compared to hepatitis B virus (HBV)).
6	15661146	Other genes dysregulated in F1-CH-C, albeit less markedly than IFN-alpha/beta- and IFN-gamma-inducible genes, were mainly involved in the activation of lymphocytes infiltrating the liver (IFNG, TNF, CXCL6, IL6, CCL8, CXCR3, CXCR4, CCR2), cell proliferation (p16/CDKN2A, MKI67, p14/ARF), extracellular matrix remodeling (MMP9, ITGA2), lymphangiogenesis (XLKD1/LYVE), oxidative stress (CYP2E1), and cytoskeleton microtubule organization (STMN2/SCG10).