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Gene Information
Gene symbol: KLRG1
Gene name: killer cell lectin-like receptor subfamily G, member 1
HGNC ID: 6380
Synonyms: MAFA, 2F1, MAFA-L, CLEC15A
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | RC3H1 | 1 hits |
| 3 | SELL | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22685317 | Naturally occurring effector CD8(+) T cells, with a KLRG1(hi) CD62L(lo) phenotype typical of short-lived effector CD8(+) T cells (SLECs), can be found in increased numbers in autoimmune-prone mice, most notably in mice homozygous for the san allele of Roquin. |
| 2 | 22685317 | When Roquin is mutated (Roquin(san)), effector CD8(+) T cells accumulate in a cell-autonomous manner, most prominently as SLEC-like effectors. |
| 3 | 22685317 | Excessive IFN-γ promotes the accumulation of SLEC-like cells, increases their T-bet expression, and enhances their granzyme B production in vivo. |
| 4 | 22685317 | This study identifies a novel mechanism that prevents accumulation of self-reactive cytotoxic effectors, highlighting the importance of regulating Ifng mRNA stability to maintain CD8(+) T cell homeostasis and prevent CD8-mediated autoimmunity. |