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Gene Information
Gene symbol: LRRK2
Gene name: leucine-rich repeat kinase 2
HGNC ID: 18618
Synonyms: ROCO2, DKFZp434H2111, FLJ45829, RIPK7
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PARK2 | 1 hits |
| 2 | VDR | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21585261 | During the early events of host-pathogen interaction identified genes are involved in pattern recognition receptors, and mycobacterial uptake (TLRs, NOD2 and MRC1), which modulate autophagy. |
| 2 | 21585261 | Together, the activation of these pathways regulates cellular metabolism upon infection, activating cytokine production through NF-κB and vitamin D-vitamin D receptor pathways, while PARK2 and LRRK2 participate in the regulation of host-cell apoptosis. |
| 3 | 21585261 | Concomitantly, genes triggered to form and maintain granulomas (TNF, LTA and IFNG) and genes involved in activating and differentiating T-helper cells (HLA, IL10, as well as the TNF/LTA axis and the IFNG/IL12 axis) bridge immunological regulation towards adaptive immunity. |