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Gene Information
Gene symbol: MAP1LC3B
Gene name: microtubule-associated protein 1 light chain 3 beta
HGNC ID: 13352
Synonyms: ATG8F
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IFNB1 | 1 hits |
| 2 | MAP1LC3A | 1 hits |
| 3 | SQSTM1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23221969 | IFNB1/interferon (IFN)-β belongs to the type I IFNs and exerts potent antiproliferative, proapoptotic, antiangiogenic and immunemodulatory functions. |
| 2 | 23221969 | We show here that IFNB1 induces autophagy in MCF-7, MDAMB231 and SKBR3 breast cancer cells by measuring the turnover of two autophagic markers, MAP1LC3B/LC3 and SQSTM1/p62. |
| 3 | 23221969 | The induction of autophagy in MCF-7 cells occurred upstream of the negative regulator of autophagy MTORC1, and autophagosome formation was dependent on the known core autophagy molecule ATG7 and the IFNB1 signaling molecule STAT1. |
| 4 | 23221969 | Using siRNA-mediated silencing of several core autophagy molecules and STAT1, we provide evidence that IFNB1 mediates its antiproliferative effects independent of autophagy, while the proapoptotic function of IFNB1 was strongly enhanced in the absence of autophagy. |