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Gene Information
Gene symbol: MAP3K14
Gene name: mitogen-activated protein kinase kinase kinase 14
HGNC ID: 6853
Synonyms: NIK, HSNIK, FTDCR1B, HS
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD14 | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | IL17A | 1 hits |
| 4 | IL1B | 1 hits |
| 5 | IL1RN | 1 hits |
| 6 | IL6 | 1 hits |
| 7 | LY96 | 1 hits |
| 8 | TLR2 | 1 hits |
| 9 | TLR4 | 1 hits |
| 10 | TLR9 | 1 hits |
| 11 | TNF | 1 hits |
| 12 | TNFAIP3 | 1 hits |
| 13 | TNFRSF1A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24776844 | Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05). |
| 2 | 24776844 | In addition, the cytokines IL-1β, IL-6 and IFN-γ may be potential targets for treating patients with IBD who do not respond to anti-TNF therapy. |