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Gene Information
Gene symbol: MAPK6
Gene name: mitogen-activated protein kinase 6
HGNC ID: 6879
Synonyms: ERK3, p97MAPK, HsT17250
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CSF3 | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | IL17A | 1 hits |
| 4 | IL6 | 1 hits |
| 5 | MAPK1 | 1 hits |
| 6 | MAPK14 | 1 hits |
| 7 | MAPK3 | 1 hits |
| 8 | NFKB1 | 1 hits |
| 9 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28239238 | Bioinformatics analysis indicated that the cytokine imbalance relevant to key molecules (such as extracellular signal-regulated kinase 1/2 (ERK1/2), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor (TNF), colony-stimulating factor 3 (CSF3), interleukin- (IL-) 6, and interferon gene (IFNG)) and canonical signaling pathways (such as the complement system, antigen presentation, macropinocytosis signaling, nuclear factor-kappa B (NF-κB) signaling, and IL-17 signaling) was responsible for the common comprehensive mechanism of PS and RA. |
| 2 | 25911310 | Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK. |
| 3 | 25911310 | Our results showed that TDZ significantly increased the mRNA expression of both brain-derived nerve factor (BDNF) and cAMP response element-binding protein (CREB) and decreased the cellular release of the pro-inflammatory cytokine interferon gamma (IFN-γ) in neuronal-like cells. |
| 4 | 25911310 | In contrast, neuronal cell treatment with LPS and TNF-α decreased the expression of CREB and BDNF and increased the expression of nuclear factor kappa B (NF-κB), a primary transcription factor that functions in inflammatory response initiation. |
| 5 | 25911310 | Moreover, the two agents induced the release of pro-inflammatory cytokines (i.e., interleukin-6 and IFN-γ) and decreased the production of the anti-inflammatory cytokine interleukin-10. |
| 6 | 25911310 | TDZ pre-treatment completely reversed the decrease in cell viability and counteracted the decrease in BDNF and CREB expression mediated by LPS-TNF-α. |
| 7 | 25911310 | TDZ induced extracellular signal-regulated kinase (ERK) phosphorylation and inhibited constitutive p38 activation. |
| 8 | 25911310 | Moreover, TDZ counteracted the activation of p38 and c-Jun NH2-terminal kinase (JNK) elicited by LPS-TNF-α, suggesting that the neuro-protective role of TDZ could be mediated by p38 and JNK. |