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Gene Information
Gene symbol: MAPKAPK3
Gene name: mitogen-activated protein kinase-activated protein kinase 3
HGNC ID: 6888
Synonyms: 3pK, MAPKAP3, 3PK
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | TH1L | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24935968 | MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection. |
| 2 | 24935968 | MK2 and MK3 are downstream targets of p38 and ERK1/2. |
| 3 | 24935968 | Using Mk-deficient and wild-type (WT) mice, we demonstrated an inhibitory effect of MK3, but not of MK2, on interferon (IFN)-γ expression in T and NK lymphocytes. |
| 4 | 24935968 | The results provided evidence that the inhibitory effect of MK3 is based on negative feedback phosphorylation of p38 and ERK1/2, which causes decreased binding of Stat4 to the IFN-γ promoter and reduced expression of IFN-γ mRNA and protein. |
| 5 | 24935968 | The reduced disease severity in the Mk3(-/-) mice was accompanied by a >10-fold reduction in viral lung titer and an increase in the number of activated NK cells and enhanced Th1 activation of CD4 T cells. |
| 6 | 24935968 | MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection. |
| 7 | 24935968 | MK2 and MK3 are downstream targets of p38 and ERK1/2. |
| 8 | 24935968 | Using Mk-deficient and wild-type (WT) mice, we demonstrated an inhibitory effect of MK3, but not of MK2, on interferon (IFN)-γ expression in T and NK lymphocytes. |
| 9 | 24935968 | The results provided evidence that the inhibitory effect of MK3 is based on negative feedback phosphorylation of p38 and ERK1/2, which causes decreased binding of Stat4 to the IFN-γ promoter and reduced expression of IFN-γ mRNA and protein. |
| 10 | 24935968 | The reduced disease severity in the Mk3(-/-) mice was accompanied by a >10-fold reduction in viral lung titer and an increase in the number of activated NK cells and enhanced Th1 activation of CD4 T cells. |