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PMID |
Sentence |
1 |
26589234
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Evidence for Epigenetic Regulation of Pro-Inflammatory Cytokines, Interleukin-12 and Interferon Gamma, in Peripheral Blood Mononuclear Cells from PTSD Patients.
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2 |
26589234
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While overall DNA methylation level did not differ significantly between control and PTSD, the promoters of several individual genes (e.g., Interferon gamma (IFNG) and Interleukin (IL)-12B) were differentially methylated.
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3 |
26589234
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ChIP-seq data revealed that the promoter of IFNG and TBX-21 was associated with the activation marker H3K4me3 in PTSD.
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4 |
26589234
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The transcript levels of both IFNG and TBX-21 were higher in PTSD correlating well with the altered methylation patterns.
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5 |
26589234
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Knockdown of lysine (K)-specific demethylase 5B (KDM5B), or inhibition of DNA (Cytosine-5-)-methyltransferase 1 (DNMT1) caused up-regulation of IL-12.
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6 |
26589234
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Our miRNA microarray identified many downregulated miRNAs in PTSD that are predicted to target IFNG and IL-12.
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7 |
26589234
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Consequently, we showed that up-regulation of hsa-miR-193a-5p could decrease the expression of IL-12.
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