Ignet

Gene Information

Gene symbol: MMP1

Gene name: matrix metallopeptidase 1 (interstitial collagenase)

HGNC ID: 7155

Related Genes

#	Gene Symbol	Number of hits
1	FGF2	1 hits
2	FLT4	1 hits
3	IFNG	1 hits
4	IL17A	1 hits
5	MMP9	1 hits
6	PGF	1 hits
7	TIMP1	1 hits

Related Sentences

#	PMID	Sentence
1	27723804	Neutrophils and the primary epithelial cells were found to express the IL-17A receptor subunit IL-17RA, while the expression of IL-17RE was only observed on epithelial cells.
2	27723804	BCG stimulation specifically reduced neutrophil IL-17RA and epithelial IL-17RE expression.
3	27723804	Infected epithelial cells and neutrophils were not found to be a source of IL-17 cytokines or the interstitial collagenase MMP-1.
4	27723804	However, the addition of IFNγ or IL-17A to BCG stimulated primary epithelial cells increased epithelial IL-6 secretion, while the presence of IFNγ reduced neutrophil recruitment.
5	27288334	The levels of four of them, including vascular endothelial growth factor receptor-3 (VEGFR3), basic fibroblast growth factor (bFGF), interferon gamma (IFNG) and matrix metalloproteinase 1 (MMP1), were quantified using western blot analysis.
6	25924700	To test the hypothesis that MMP expression in luteal cells is regulated by luteolytic factors, we investigated the effects of prostaglandin F2α (PGF), interferon γ (IFNG) and tumor necrosis factor α (TNF) on the mRNA expression of MMPs and TIMPs in cultured luteal cells.
7	25924700	To test the hypothesis that MMP expression in luteal cells is regulated by luteolytic factors, we investigated the effects of prostaglandin F2α (PGF), interferon γ (IFNG) and tumor necrosis factor α (TNF) on the mRNA expression of MMPs and TIMPs in cultured luteal cells.
8	25924700	To test the hypothesis that MMP expression in luteal cells is regulated by luteolytic factors, we investigated the effects of prostaglandin F2α (PGF), interferon γ (IFNG) and tumor necrosis factor α (TNF) on the mRNA expression of MMPs and TIMPs in cultured luteal cells.
9	25924700	Luteal cells obtained from the CL at the mid-luteal stage (days 8-12 after ovulation) were cultured with PGF (0.01, 0.1, 1 μM), IFNG (0.05, 0.5, 5 nM) and TNF (0.05, 0.5, 0.5 nM) alone or in combination for 24 h.
10	25924700	Luteal cells obtained from the CL at the mid-luteal stage (days 8-12 after ovulation) were cultured with PGF (0.01, 0.1, 1 μM), IFNG (0.05, 0.5, 5 nM) and TNF (0.05, 0.5, 0.5 nM) alone or in combination for 24 h.
11	25924700	Luteal cells obtained from the CL at the mid-luteal stage (days 8-12 after ovulation) were cultured with PGF (0.01, 0.1, 1 μM), IFNG (0.05, 0.5, 5 nM) and TNF (0.05, 0.5, 0.5 nM) alone or in combination for 24 h.
12	25924700	PGF and IFNG significantly increased the expression of MMP-1 mRNA.
13	25924700	PGF and IFNG significantly increased the expression of MMP-1 mRNA.
14	25924700	PGF and IFNG significantly increased the expression of MMP-1 mRNA.
15	25924700	In addition, 1 μM PGF in combination with 5 nM IFNG stimulated MMP-1 and MMP-9 mRNA expression significantly more than either treatment alone.
16	25924700	In addition, 1 μM PGF in combination with 5 nM IFNG stimulated MMP-1 and MMP-9 mRNA expression significantly more than either treatment alone.
17	25924700	In addition, 1 μM PGF in combination with 5 nM IFNG stimulated MMP-1 and MMP-9 mRNA expression significantly more than either treatment alone.
18	25924700	In contrast, IFNG significantly decreased the level of MMP-14 mRNA.
19	25924700	In contrast, IFNG significantly decreased the level of MMP-14 mRNA.
20	25924700	In contrast, IFNG significantly decreased the level of MMP-14 mRNA.
21	25924700	The mRNA expression of TIMP-1, which preferentially inhibits MMP-1, was suppressed by 5 nM INFG.
22	25924700	The mRNA expression of TIMP-1, which preferentially inhibits MMP-1, was suppressed by 5 nM INFG.
23	25924700	The mRNA expression of TIMP-1, which preferentially inhibits MMP-1, was suppressed by 5 nM INFG.
24	25924700	One μM PGF and 5 nM IFNG suppressed TIMP-2 mRNA expression.
25	25924700	One μM PGF and 5 nM IFNG suppressed TIMP-2 mRNA expression.
26	25924700	One μM PGF and 5 nM IFNG suppressed TIMP-2 mRNA expression.
27	25924700	These results suggest a new role of MMPs: luteal MMPs stimulated by PGF and IFNG break down the extracellular matrix surrounding luteal cells, which accelerates detachment from the CL during luteolysis, providing an essential prerequisite for outflow of luteal cells from the CL to lymphatic vessels.
28	25924700	These results suggest a new role of MMPs: luteal MMPs stimulated by PGF and IFNG break down the extracellular matrix surrounding luteal cells, which accelerates detachment from the CL during luteolysis, providing an essential prerequisite for outflow of luteal cells from the CL to lymphatic vessels.
29	25924700	These results suggest a new role of MMPs: luteal MMPs stimulated by PGF and IFNG break down the extracellular matrix surrounding luteal cells, which accelerates detachment from the CL during luteolysis, providing an essential prerequisite for outflow of luteal cells from the CL to lymphatic vessels.