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Gene Information
Gene symbol: MYST2
Gene name: MYST histone acetyltransferase 2
HGNC ID: 17016
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EOMES | 1 hits |
| 2 | HTATIP | 1 hits |
| 3 | ZBTB7B | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23609452 | 60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells. |
| 2 | 23609452 | The abundant expression of IFNγ in Th-inducing POK (ThPOK)-deficient CD4(+) T cells requires the activation of Eomesodermin (Eomes); however, the underlying mechanism of this phenomenon remains unclear. |
| 3 | 23609452 | Here we report that ThPOK binds directly to the promoter region of the Eomes gene to repress its expression in CD4(+) T cells. |
| 4 | 23609452 | We identified the histone acetyltransferase TIP60 as a co-repressor of ThPOK-target genes, where ectopically expressed TIP60 increased ThPOK protein stability by promoting its acetylation at its Lys(360) residue to then augment the transcriptional repression of Eomes. |
| 5 | 23609452 | Moreover, knockdown of endogenous TIP60 abolished the stabilization of ThPOK in CD4(+) T cells, which led to the transcriptional activation of Eomes and increased production of IFNγ. |
| 6 | 23609452 | Our results reveal a novel pathway by which TIP60 and ThPOK synergistically suppresses Eomes function and IFNγ production, which could contribute to the regulation of inflammation. |