Ignet

Gene Information

Gene symbol: NOD2

Gene name: nucleotide-binding oligomerization domain containing 2

HGNC ID: 5331

Synonyms: BLAU, CD, PSORAS1, CLR16.3, NLRC2

Related Genes

#	Gene Symbol	Number of hits
1	AIM2	1 hits
2	CASP1	1 hits
3	HMGB1	1 hits
4	IFNG	1 hits
5	IL10	1 hits
6	IL1A	1 hits
7	IL1B	1 hits
8	IL6	1 hits
9	LTA	1 hits
10	MMP9	1 hits
11	MRC1	1 hits
12	NFKB1	1 hits
13	NLRP3	1 hits
14	NOD1	1 hits
15	SOD2	1 hits
16	TLR1	1 hits
17	TNF	1 hits

Related Sentences

#	PMID	Sentence
1	28715406	Genetic polymorphisms of the IL6 and NOD2 genes are risk factors for inflammatory reactions in leprosy.
2	28715406	Genetic polymorphisms of the IL6 and NOD2 genes are risk factors for inflammatory reactions in leprosy.
3	28715406	Genetic polymorphisms of the IL6 and NOD2 genes are risk factors for inflammatory reactions in leprosy.
4	28715406	Genetic polymorphisms of the IL6 and NOD2 genes are risk factors for inflammatory reactions in leprosy.
5	28715406	From the 15 single nucleotide polymorphisms (SNPs) at the 8 candidate genes genotyped (TNF/LTA, IFNG, IL10, TLR1, NOD2, SOD2, and IL6) we observed statistically different survival curves for rs751271 at the NOD2 and rs2069845 at the IL6 genes (log-rank p-values = 0.002 and 0.023, respectively), suggesting an influence on the amount of time before developing leprosy reactions.
6	28715406	From the 15 single nucleotide polymorphisms (SNPs) at the 8 candidate genes genotyped (TNF/LTA, IFNG, IL10, TLR1, NOD2, SOD2, and IL6) we observed statistically different survival curves for rs751271 at the NOD2 and rs2069845 at the IL6 genes (log-rank p-values = 0.002 and 0.023, respectively), suggesting an influence on the amount of time before developing leprosy reactions.
7	28715406	From the 15 single nucleotide polymorphisms (SNPs) at the 8 candidate genes genotyped (TNF/LTA, IFNG, IL10, TLR1, NOD2, SOD2, and IL6) we observed statistically different survival curves for rs751271 at the NOD2 and rs2069845 at the IL6 genes (log-rank p-values = 0.002 and 0.023, respectively), suggesting an influence on the amount of time before developing leprosy reactions.
8	28715406	From the 15 single nucleotide polymorphisms (SNPs) at the 8 candidate genes genotyped (TNF/LTA, IFNG, IL10, TLR1, NOD2, SOD2, and IL6) we observed statistically different survival curves for rs751271 at the NOD2 and rs2069845 at the IL6 genes (log-rank p-values = 0.002 and 0.023, respectively), suggesting an influence on the amount of time before developing leprosy reactions.
9	28715406	Cox models showed associations between the SNPs rs751271 at NOD2 and rs2069845 at IL6 with leprosy reactions (HRGT = 0.45, p = 0.002; HRAG = 1.88, p = 0.0008, respectively).
10	28715406	Cox models showed associations between the SNPs rs751271 at NOD2 and rs2069845 at IL6 with leprosy reactions (HRGT = 0.45, p = 0.002; HRAG = 1.88, p = 0.0008, respectively).
11	28715406	Cox models showed associations between the SNPs rs751271 at NOD2 and rs2069845 at IL6 with leprosy reactions (HRGT = 0.45, p = 0.002; HRAG = 1.88, p = 0.0008, respectively).
12	28715406	Cox models showed associations between the SNPs rs751271 at NOD2 and rs2069845 at IL6 with leprosy reactions (HRGT = 0.45, p = 0.002; HRAG = 1.88, p = 0.0008, respectively).
13	28715406	Finally, IL-6 and IFN-γ levels were confirmed as high, while IL-10 titers were low in the sera of reactional patients.
14	28715406	Finally, IL-6 and IFN-γ levels were confirmed as high, while IL-10 titers were low in the sera of reactional patients.
15	28715406	Finally, IL-6 and IFN-γ levels were confirmed as high, while IL-10 titers were low in the sera of reactional patients.
16	28715406	Finally, IL-6 and IFN-γ levels were confirmed as high, while IL-10 titers were low in the sera of reactional patients.
17	28715406	From the results, we conclude that SNPs at the NOD2 and IL6 genes are associated with leprosy reactions as an outcome.
18	28715406	From the results, we conclude that SNPs at the NOD2 and IL6 genes are associated with leprosy reactions as an outcome.
19	28715406	From the results, we conclude that SNPs at the NOD2 and IL6 genes are associated with leprosy reactions as an outcome.
20	28715406	From the results, we conclude that SNPs at the NOD2 and IL6 genes are associated with leprosy reactions as an outcome.
21	27806943	Incubation of the chorioamniotic membranes with HMGB1 1) induced the release of mature IL-1beta and IL-6; 2) upregulated the mRNA expression of the pro-inflammatory mediators NFKB1, IL6, TNF, IL1A, IFNG, and HMGB1 receptors RAGE and TLR2; 3) upregulated the mRNA expression of the inflammasome components NLRP3 and AIM2 as well as NOD proteins (NOD1 and NOD2); 4) increased the protein concentrations of NLRP3 and NOD2; 5) increased the concentration of caspase-1 and the quantity of its active form (p20); and 6) upregulated the mRNA expression and active form of MMP-9.
22	21585261	During the early events of host-pathogen interaction identified genes are involved in pattern recognition receptors, and mycobacterial uptake (TLRs, NOD2 and MRC1), which modulate autophagy.
23	21585261	Together, the activation of these pathways regulates cellular metabolism upon infection, activating cytokine production through NF-κB and vitamin D-vitamin D receptor pathways, while PARK2 and LRRK2 participate in the regulation of host-cell apoptosis.
24	21585261	Concomitantly, genes triggered to form and maintain granulomas (TNF, LTA and IFNG) and genes involved in activating and differentiating T-helper cells (HLA, IL10, as well as the TNF/LTA axis and the IFNG/IL12 axis) bridge immunological regulation towards adaptive immunity.