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Gene Information
Gene symbol: NOTCH4
Gene name: notch 4
HGNC ID: 7884
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DLL1 | 1 hits |
| 2 | DLL4 | 1 hits |
| 3 | HES1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25041739 | Dengue virus up-regulates expression of notch ligands Dll1 and Dll4 through interferon-β signalling pathway. |
| 2 | 25041739 | The real-time PCR data showed that Notch ligand Dll1 was significantly induced in DENV-infected monocytes; and receptor Notch4, ligands Dll1 and Dll4, and target Hes1 were dramatically enhanced in DENV-infected macrophages and dendritic cells. |
| 3 | 25041739 | In macrophages, induction of Dll1 and Dll4 mediated by DENV2 was increased by treatment with interferon-β (IFN-β), and was impaired by neutralization of IFN-β. |
| 4 | 25041739 | The DENV-induced Dll1 and Dll4 expression level was decreased by silencing key innate immune molecules, including Toll-like receptor 3 (TLR3), MyD88, RIG-I and IPS-I. |
| 5 | 25041739 | In IFN-receptor-depleted macrophages, the Dll1 and Dll4 induction was significantly alleviated. |
| 6 | 25041739 | Functionally, activation of Notch signalling by Dll1 in CD4(+) T cells enhanced the expression of a T helper type 1 (Th1) cytokine IFN-γ, while Notch activation in macrophages had no direct effect on replication of DENV. |