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Gene Information

Gene symbol: NR3C1

Gene name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

HGNC ID: 7978

Synonyms: GR

Related Genes

#	Gene Symbol	Number of hits
1	CASP3	1 hits
2	CASP8	1 hits
3	CXCL10	1 hits
4	HSD11B1	1 hits
5	HSD11B2	1 hits
6	IFNG	1 hits
7	TNF	1 hits

Related Sentences

#	PMID	Sentence
1	28679952	We show high levels of CXCL10 mRNA closely associated with IFNG levels in the BAL cells of 50% of severe asthmatics and also in the airways of mice subjected to a severe asthma model, both in the context of high-dose CS treatment.
2	28679952	The inability of CS to dampen IFNG or CXCL10 expression was not because of impaired nuclear translocation of the glucocorticoid receptor (GR) or its transactivational functions.
3	28679952	Rather, in the presence of CS and IFN-γ, STAT1 and GR were recruited on critical regulatory elements in the endogenous CXCL10 promoter in monocytes, albeit without any abatement of CXCL10 gene expression.
4	18218610	Cortisol (an active GC) reduced the mRNA expression of caspase 8 (CASP8) and caspase 3 (CASP3) and reduced the enzymatic activity of CASP3 and cell death induced by tumor necrosis factor (TNF) and interferon gamma (IFNG) in cultured bovine luteal cells. mRNAs and proteins of GC receptor (NR3C1), 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1), and HSD11B2 were expressed in CL throughout the estrous cycle.
5	18218610	These results suggest that cortisol suppresses TNF-IFNG-induced apoptosis in vitro by reducing apoptosis signals via CASP8 and CASP3 in bovine CL and that the local increase in cortisol production resulting from increased HSD11B1 at the early and midluteal stages helps to maintain CL function by suppressing apoptosis of luteal cells.