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Gene Information

Gene symbol: OAS2

Gene name: 2'-5'-oligoadenylate synthetase 2, 69/71kDa

HGNC ID: 8087

Related Genes

#	Gene Symbol	Number of hits
1	CXCL10	1 hits
2	CXCL11	1 hits
3	CXCL9	1 hits
4	IFI27	1 hits
5	IFI6	1 hits
6	IFNA1	1 hits
7	IFNG	1 hits
8	IRF9	1 hits
9	ISG15	1 hits
10	MX1	1 hits
11	OAS1	1 hits
12	OAS3	1 hits
13	OASL	1 hits
14	STAT1	1 hits
15	STAT2	1 hits

Related Sentences

#	PMID	Sentence
1	15661146	The most noteworthy changes in gene expression mainly affected the transcriptional network regulated by interferons (IFNs), including both IFN-alpha/beta-inducible genes (STAT1, STAT2, ISGF3G/IRF9, IFI27, G1P3, G1P2, OAS2, MX1) and IFN-gamma-inducible genes (CXCL9, CXCL10, CXCL11).
2	15661146	Interesting, upregulation of IFN-alpha/beta-inducible genes (but not IFN-gamma-inducible genes) was independent of histological scores (grade and stage of fibrosis) and HCV characteristics (hepatic HCV mRNA levels and the HCV genotype), and was specific to HCV (as compared to hepatitis B virus (HBV)).
3	15661146	Other genes dysregulated in F1-CH-C, albeit less markedly than IFN-alpha/beta- and IFN-gamma-inducible genes, were mainly involved in the activation of lymphocytes infiltrating the liver (IFNG, TNF, CXCL6, IL6, CCL8, CXCR3, CXCR4, CCR2), cell proliferation (p16/CDKN2A, MKI67, p14/ARF), extracellular matrix remodeling (MMP9, ITGA2), lymphangiogenesis (XLKD1/LYVE), oxidative stress (CYP2E1), and cytoskeleton microtubule organization (STMN2/SCG10).
4	28444539	The 2'5'-oligoadenylate synthetase (OAS) is an interferon (IFN)-induced protein that plays an important role in the antiviral action of IFN, with OAS3 being one of the four OAS classes (OAS1, OAS2, OAS3, OASL).