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Gene Information
Gene symbol: PARK2
Gene name: parkinson protein 2, E3 ubiquitin protein ligase (parkin)
HGNC ID: 8607
Synonyms: PDJ, AR-JP, parkin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HIF1A | 1 hits |
| 2 | LRRK2 | 1 hits |
| 3 | VDR | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26084024 | E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity. |
| 2 | 26084024 | Mice with Foxp3-restricted VHL deletion displayed massive inflammation associated with excessive Treg cell interferon-γ (IFN-γ) production. |
| 3 | 26084024 | Augmented hypoxia-inducible factor 1α (HIF-1α)-induced glycolytic reprogramming was required for IFN-γ production. |
| 4 | 26084024 | Furthermore, HIF-1α bound directly to the Ifng promoter. |
| 5 | 21585261 | During the early events of host-pathogen interaction identified genes are involved in pattern recognition receptors, and mycobacterial uptake (TLRs, NOD2 and MRC1), which modulate autophagy. |
| 6 | 21585261 | Together, the activation of these pathways regulates cellular metabolism upon infection, activating cytokine production through NF-κB and vitamin D-vitamin D receptor pathways, while PARK2 and LRRK2 participate in the regulation of host-cell apoptosis. |
| 7 | 21585261 | Concomitantly, genes triggered to form and maintain granulomas (TNF, LTA and IFNG) and genes involved in activating and differentiating T-helper cells (HLA, IL10, as well as the TNF/LTA axis and the IFNG/IL12 axis) bridge immunological regulation towards adaptive immunity. |