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Gene Information
Gene symbol: PCNA
Gene name: proliferating cell nuclear antigen
HGNC ID: 8729
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD38 | 1 hits |
| 2 | IL17A | 1 hits |
| 3 | MKI67 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 24489445 | CD38 ligation in peripheral blood mononuclear cells of myeloma patients induces release of protumorigenic IL-6 and impaired secretion of IFNγ cytokines and proliferation. |
| 2 | 24489445 | The impaired CD38-dependent proliferative response likely reflects an arrest in the progression of cell cycle, as indicated by the reduced expression of PCNA. |
| 3 | 24489445 | CD38 signaling showed an enhanced ability to induce IL-6 secretion. |
| 4 | 24489445 | PBMC from MM patients displays a deregulated response possibly due to defects of CD38 activation pathways and CD38 may be functionally involved in the progression of this pathology via the secretion of high levels of IL-6 that protects neoplastic cells from apoptosis. |
| 5 | 24249741 | SerpinB1 regulates homeostatic expansion of IL-17+ γδ and CD4+ Th17 cells. |
| 6 | 24249741 | Here, we show that IL-17A(+) γδ and CD4(+) Th17 cells are already expanded in the lungs of serpinb1a(-/-) mice at steady-state. |
| 7 | 24249741 | Both γδ and αβ(+) CD4(+) CCR6(+) T cells isolated from the lungs of naive serpinb1a(-/-) mice displayed a skewed transcriptional profile relative to WT cells, including increased Th17 signature transcripts [Il17a, l17f, and Rorc (RORγt)] and decreased Th1 signature transcripts [Ifng, Cxcr3, and Tbx21 (T-bet)] in γδ T cells. |
| 8 | 24249741 | In addition to the lung, IL-17A(+) γδ and CD4(+) Th17 cells were increased in the spleen of naive serpinb1a(-/-) mice, despite normal αβ and γδ T cell development in the thymus. |
| 9 | 24249741 | Within the γδ T cell compartment, loss of serpinb1a prompted selective expansion of Vγ4(+) and Vγ6/Vδ1(+) cells, which also displayed elevated expression of the proliferating cell nuclear antigen, Ki-67, and IL-17A. |
| 10 | 24249741 | Given that serpinb1a is preferentially expressed in WT IL-17A(+) γδ and CD4(+) Th17 cell subsets vis-à-vis other T cell lineages, our findings reveal a novel function of serpinB1 in limiting untoward expansion of lymphocytes with a Th17 phenotype. |