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Gene Information
Gene symbol: PCSK1
Gene name: proprotein convertase subtilisin/kexin type 1
HGNC ID: 8743
Synonyms: PC1, PC3, SPC3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CASP3 | 1 hits |
| 2 | CASP8 | 1 hits |
| 3 | RIPK1 | 1 hits |
| 4 | RIPK3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 27901113 | In the present study, to determine if necroptosis participates in bovine structural luteolysis, we investigated RIPK1 and RIPK3 expression throughout the estrous cycle, during prostaglandin F2α (PGF)-induced luteolysis in the bovine corpus luteum (CL), and in cultured luteal steroidogenic cells (LSCs) after treatment with selected luteolytic factors. |
| 2 | 27901113 | In the present study, to determine if necroptosis participates in bovine structural luteolysis, we investigated RIPK1 and RIPK3 expression throughout the estrous cycle, during prostaglandin F2α (PGF)-induced luteolysis in the bovine corpus luteum (CL), and in cultured luteal steroidogenic cells (LSCs) after treatment with selected luteolytic factors. |
| 3 | 27901113 | In the present study, to determine if necroptosis participates in bovine structural luteolysis, we investigated RIPK1 and RIPK3 expression throughout the estrous cycle, during prostaglandin F2α (PGF)-induced luteolysis in the bovine corpus luteum (CL), and in cultured luteal steroidogenic cells (LSCs) after treatment with selected luteolytic factors. |
| 4 | 27901113 | In addition, effects of a RIPK1 inhibitor (necrostatin-1, Nec-1; 50 μM) on cell viability, progesterone secretion, apoptosis related factors and RIPKs expression, were evaluated. |
| 5 | 27901113 | In addition, effects of a RIPK1 inhibitor (necrostatin-1, Nec-1; 50 μM) on cell viability, progesterone secretion, apoptosis related factors and RIPKs expression, were evaluated. |
| 6 | 27901113 | In addition, effects of a RIPK1 inhibitor (necrostatin-1, Nec-1; 50 μM) on cell viability, progesterone secretion, apoptosis related factors and RIPKs expression, were evaluated. |
| 7 | 27901113 | Expression of RIPK1 and RIPK3 increased in the CL tissue during both spontaneous and PGF-induced luteolysis (P < 0.05). |
| 8 | 27901113 | Expression of RIPK1 and RIPK3 increased in the CL tissue during both spontaneous and PGF-induced luteolysis (P < 0.05). |
| 9 | 27901113 | Expression of RIPK1 and RIPK3 increased in the CL tissue during both spontaneous and PGF-induced luteolysis (P < 0.05). |
| 10 | 27901113 | In cultured LSCs, tumor necrosis factor α (TNF; 2.3 nM) in combination with interferon γ (IFNG; 2.5 nM) up-regulated RIPK1 mRNA and protein expression (P < 0.05). |
| 11 | 27901113 | In cultured LSCs, tumor necrosis factor α (TNF; 2.3 nM) in combination with interferon γ (IFNG; 2.5 nM) up-regulated RIPK1 mRNA and protein expression (P < 0.05). |
| 12 | 27901113 | In cultured LSCs, tumor necrosis factor α (TNF; 2.3 nM) in combination with interferon γ (IFNG; 2.5 nM) up-regulated RIPK1 mRNA and protein expression (P < 0.05). |
| 13 | 27901113 | Although Nec-1 prevented TNF + IFNG-induced cell death (P < 0.05), it did not affect CASP3 and CASP8 expression. |
| 14 | 27901113 | Although Nec-1 prevented TNF + IFNG-induced cell death (P < 0.05), it did not affect CASP3 and CASP8 expression. |
| 15 | 27901113 | Although Nec-1 prevented TNF + IFNG-induced cell death (P < 0.05), it did not affect CASP3 and CASP8 expression. |
| 16 | 27901113 | Nec-1 decreased both RIPK1 and RIPK3 protein expression (P < 0.05). |
| 17 | 27901113 | Nec-1 decreased both RIPK1 and RIPK3 protein expression (P < 0.05). |
| 18 | 27901113 | Nec-1 decreased both RIPK1 and RIPK3 protein expression (P < 0.05). |